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Autor:
Lu Cai, Yuanyuan Tian, Madhavi J. Rane, Xiangyu Zheng, Wenjing Song, Yuguang Zhao, Zhenyu Wang
Publikováno v:
Toxicology and applied pharmacology. 427
Diabetic cardiomyopathy (DCM) is a serious diabetic complication that lacks effective preventive or therapeutic approaches. Wild-type and Klf15 knockout (Klf15-KO) mice were fed with either high fat diet (HFD, 60% kcal from fat) or normal diet (ND, 1
Publikováno v:
Toxicology and applied pharmacology. 427
Mitochondrial injury contributes to severe drug-induced liver injury. Particularly, mitochondrial permeability transition (MPT) is thought to be relevant to cytolytic hepatitis. However, the mechanism of drug-induced MPT is unclear and prediction of
Autor:
Sandra Maria Miraglia, Vanessa Vendramini, G.S. Souza, J.C. Souza, Camila Cicconi Paccola, I.M.M. Freitas, L.L. Martins
Publikováno v:
Toxicology and applied pharmacology. 426
Gonadal development begins in the intrauterine phase and females from most species are born with an established oocyte reserve. Exposure to drugs during gestation can compromise the offspring health, also affecting the gametes quality. Nicotine, the
Autor:
Marko Vasić, Csenger Kovácsházi, Marija Kosić, Vladislav Pajović, Gábor B. Brenner, Zoltán Giricz, Péter Ferdinandy, Dragana Bajic, Ljiljana Đukić, Nina Japundžić-Žigon
Publikováno v:
Toxicology and applied pharmacology. 423
Cardiomyopathy resistant to treatment is the most serious adverse effect of doxorubicin (dox). The mechanisms of dox-induced cardiomyopathy (DCM) have been extensively studied in dilated forms of DCM. However, efficient treatment did not emerge. The
Autor:
Mahmoud M. El-Mas, Yasser H. Habib, Nevine M. El-Deeb, Sherien A. Abdelhady, Mennatallah A. Gowayed, Inas E. Darwish
Publikováno v:
Toxicology and applied pharmacology. 426
Current therapies for preeclampsia (PE) and its complications are limited and defective. Considering the importance of endothelin (ET) and thromboxane A2 (TXA2) signaling in PE pathophysiology, we tested the hypothesis that prenatal blockade of endot
Publikováno v:
Toxicology and applied pharmacology. 423
The expression of transporters on the apical and basal membranes of renal proximal tubular cells are down- or upregulated to various extents under cisplatin (CDDP)-induced acute kidney injury (AKI). However, little is known about the changes in trans
Publikováno v:
Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2019, 375, pp.46-56. ⟨10.1016/j.taap.2019.05.002⟩
Toxicology and Applied Pharmacology, Elsevier, 2019, 375, pp.46-56. ⟨10.1016/j.taap.2019.05.002⟩
Our previous studies showed that prenatal ethanol exposure (PEE) elevated blood total cholesterol (TCH) level in adult offspring rats. This study was aimed at elucidating the intrauterine programming mechanism of hypercholesterolemia in adult rats in
Autor:
Manuela Verri, Francesco Paolo Fanizzi, Graziella Bernocchi, Maddalena Grimaldi, Maria Grazia Bottone, Beatrice Ferrari, Paola Veneroni, Sandra Angelica De Pascali, Fabrizio De Luca, Elisa Roda, Sergio Barni, Veronica Dal Bo
Publikováno v:
Toxicology and Applied Pharmacology. 364:1-11
Cisplatin (cisPt), among the best known components of multi-drug front-line therapies used for the treatments of solid tumors, such as the childhood neuroblastoma, acts through DNA linking. Nevertheless, the cisPt effectiveness is compromised by the
Autor:
Pedro Batista, Vanessa Jóia de Mello, Moisés Hamoy, Marcelo Ferreira Torres, Rômulo Augusto Feio Farias, Jason G. Taylor, Helcio Casemiro Marcondes, Luiz dos Santos Batista, Luis André Luz Barbas, William D. Hutchison, José Luiz Martins do Nascimento, Walace Gomes-Leal
Publikováno v:
Toxicology and Applied Pharmacology. 360:193-200
This study aimed at describing the characteristics and properties of seizures induced by cunaniol, a polyacetylenic alcohol isolated from the Clibadium genus, which is ubiquitous in the Amazon biodiversity and its potential use as a convulsant model.
Publikováno v:
Toxicology and Applied Pharmacology. 360:78-87
Various rodent models of statin-associated muscle symptoms (SAMS) have been used to investigate the aetiology of statin myotoxicity. Variability between these models, however, may be contributing to the ambiguity currently surrounding the pathogenesi