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Autor:
Zhikun Zhan, Shuwen Liu, Han Liu, Zheng Cai, Menghua Liu, Zhi Liang, Lan Tang, Ling Ye, Yulian Chen, Lili Wu, Tao Zhang, Jie Zhao
Publikováno v:
Toxicology and Applied Pharmacology. 359:91-101
Aggravating effect of probenecid (a traditional anti-gout agent) on emodin-induced hepatotoxicity was evaluated in this study. 33.3% rats died in combination group, while no death was observed in rats treated with emodin alone or probenecid alone, in
Autor:
Mahmoud M. El-Mas, Yasser H. Habib, Nevine M. El-Deeb, Sherien A. Abdelhady, Mennatallah A. Gowayed, Inas E. Darwish
Publikováno v:
Toxicology and applied pharmacology. 426
Current therapies for preeclampsia (PE) and its complications are limited and defective. Considering the importance of endothelin (ET) and thromboxane A2 (TXA2) signaling in PE pathophysiology, we tested the hypothesis that prenatal blockade of endot
Publikováno v:
Toxicology and applied pharmacology. 423
The expression of transporters on the apical and basal membranes of renal proximal tubular cells are down- or upregulated to various extents under cisplatin (CDDP)-induced acute kidney injury (AKI). However, little is known about the changes in trans
Autor:
Damien Richard, Alain Eschalier, Raalib Amode, Julie Vein, Bruno Pereira, Yohann Wittrant, Aurore Collin, Christelle Guillet, David Balayssac
Publikováno v:
Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2021, 425, pp.115600. ⟨10.1016/j.taap.2021.115600⟩
Toxicology and Applied Pharmacology, 2021, 425, pp.115600. ⟨10.1016/j.taap.2021.115600⟩
Toxicology and Applied Pharmacology, Elsevier, 2021, 425, pp.115600. ⟨10.1016/j.taap.2021.115600⟩
Toxicology and Applied Pharmacology, 2021, 425, pp.115600. ⟨10.1016/j.taap.2021.115600⟩
International audience; Among postmenopausal women with estrogen receptor-positive breast cancer, more than 80% receive hormone therapy including aromatase inhibitors (AIs). Half of them develop chronic arthralgia - characterized by symmetric articul
Autor:
Zongmian Song, Pan Lu, Zhongpei Zhu, Xu Yan, Hongjian Liu, Songfeng Chen, Chen Jian, Chao Dong, Jing Chen, Yongkui Wang
Publikováno v:
Toxicology and applied pharmacology. 409
Glucocorticoids have been widely used in multiple inflammatory and autoimmune diseases. However, long-term glucocorticoid therapy may result in osteoporosis. The present study aimed to evaluate the potential therapeutic effects and investigate the un
Autor:
Zuzana Babinská, Tibor Štark, Hana Kotolová, Tomáš Hammer, Jiri Prochazka, Katerina Horska, Michal Karpisek, Vincenzo Micale, Jana Ruda-Kucerova
Publikováno v:
Toxicology and applied pharmacology. 406
Mortality in psychiatric patients with severe mental illnesses reaches a 2-3 times higher mortality rate compared to the general population, primarily due to somatic comorbidities. A high prevalence of cardiovascular morbidity can be attributed to th
Publikováno v:
Toxicology and applied pharmacology. 399
The cardiotoxicity caused by doxorubicin and extravasation injury caused by anthracyclines is reduced by the clinically approved bisdioxopiperazine drug dexrazoxane. Dexrazoxane is a rings-closed analog of EDTA and is hydrolyzed in vivo to a form tha
Autor:
Adi Neufeld-Cohen, Shlomi Baranes, Ariel Gore, Shira Chapman, Ettie Grauer, Shlomi Lazar, Inbal Egoz, Rellie Gez
Publikováno v:
Toxicology and applied pharmacology. 395
Background Sarin is an irreversible organophosphate cholinesterase inhibitor. Following toxic signs, an extensive long-term brain damage is often reported. Thus, we evaluated the efficacy of a novel anticonvulsant drug retigabine, a modulator of neur
Autor:
Dalaal M. Abdallah, Dalia M. Abouelfadl, Muhammad Y. Al-Shorbagy, Doaa A. Zaky, Noha N. Nassar
Publikováno v:
Toxicology and applied pharmacology. 394
Proper enterocytic proliferation/differentiation, besides providing adequate adherens junctions (AJ) integrity, are responsible for strengthening of the gut barrier that acts as a first line defense against endotoxemia. However, the preferential role
Autor:
Seth Gibbs, Heather Toy, Natalie L. South, Suramya Waidyanatha, Esra Mutlu, Natasha R. Catlin, Brian L. Burback, Barry S. McIntyre
Publikováno v:
Toxicology and Applied Pharmacology. 338:83-92
Vinpocetine is being used worldwide by people of all ages, including pregnant women, for its purported multiple health benefits. However, limited data is available addressing the safety/toxicity of vinpocetine. The National Toxicology Program conduct