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Autor:
Zhikun Zhan, Shuwen Liu, Han Liu, Zheng Cai, Menghua Liu, Zhi Liang, Lan Tang, Ling Ye, Yulian Chen, Lili Wu, Tao Zhang, Jie Zhao
Publikováno v:
Toxicology and Applied Pharmacology. 359:91-101
Aggravating effect of probenecid (a traditional anti-gout agent) on emodin-induced hepatotoxicity was evaluated in this study. 33.3% rats died in combination group, while no death was observed in rats treated with emodin alone or probenecid alone, in
Autor:
Liang-Liang Zhu, Yan Wu, Huili Wang, Minyi Huang, Ling Xiao, Yang-Liu Xia, Guang-Bo Ge, Kun Zhou, Ling Yang, Ganlin Wu
Publikováno v:
Toxicology and Applied Pharmacology. 283:109-116
This in vitro study investigates the effects of diethylstilbestrol (DES), a widely used toxic synthetic estrogen, on estradiol-3- and 17-O- (E2-3/17-O) glucuronidation, via culturing human liver microsomes (HLMs) or recombinant UDP-glucuronosyltransf
Autor:
Seigo Sanoh, Shigeru Ohta, Yoko Watanabe, Naoto Uramaru, Kazumi Sugihara, Hiroyuki Kojima, Shigeyuki Kitamura, Shinji Takeuchi
Publikováno v:
Toxicology and Applied Pharmacology. 282:119-128
Benzophenone-3 (2-hydroxy-4-methoxybenzophenone; BP-3) is widely used as sunscreen for protection of human skin and hair from damage by ultraviolet (UV) radiation. In this study, we examined the metabolism of BP-3 by rat and human liver microsomes, a
Publikováno v:
Toxicology and Applied Pharmacology. 248:38-44
Microsomal enzyme inducers (MEI) that increase UDP-glucuronosyltransferases (UGTs) are thought to increase glucuronidation of thyroxine (T(4)), thus reducing serum T(4), and subsequently increasing thyroid stimulating hormone (TSH). Ugt1a1 and Ugt1a6
Publikováno v:
Toxicology and Applied Pharmacology. 210:32-38
Tributyltin is metabolized by cytochrome P-450 (CYP) system enzymes, and its metabolic fate may contribute to the toxicity of the chemical. In the present study, it is examined whether sex differences in the metabolism of tributyltin exist in rats. I
Publikováno v:
Toxicology and Applied Pharmacology. 196:20-28
Male and female of F344 rats were treated per os with nicardipine (Nic) and nifedipine (Nif), and changes in the levels of mRNA and protein of hepatic cytochrome P450 (P450) enzymes, CYP2B1, CYP2B2, CYP3A1, CYP3A2, CYP3A9, and CYP3A18 were examined.
Autor:
Curtis D. Klaassen, David R. Johnson
Publikováno v:
Toxicology and Applied Pharmacology. 180:56-63
We have previously demonstrated that microsomal enzyme inducers phenobarbital (PB) and pregnenolone-16alpha-carbonitrile (PCN), but not 3-methylcholanthrene (3-MC) and benzo(a)pyrene (BaP), increase expression and function of rat Multidrug Resistance
Publikováno v:
Toxicology and Applied Pharmacology. 156:195-205
The in vitro metabolism of chlorotriazines, simazine (SIZ), atrazine (ATZ), and propazine (PRZ) was studied using control, 3-methylcholanthrene-, phenobarbital-, pyridine-, dexamethasone-, and clofibrate-treated rat liver microsomes. The metabolites
Publikováno v:
Toxicology and Applied Pharmacology. 143:420-428
The reductive metabolic activation of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123), one of the potential substitutes for the ozone-depleting chlorofluorocarbons and a close structural analogue of the hepatotoxic anesthetic halothane, was investigate
Publikováno v:
Toxicology and Applied Pharmacology. 135:179-184
CYP1A1 gene expression is regulated by known cis- and transacting elements controlling inhibition and induction of CYP1A1 transcription. The influence of a double-stranded phosphorothioate oligonucleotide (dsODN) with sequence identical to the CYP1A1