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Publikováno v:
Toxicology and Applied Pharmacology. 160:163-170
The microsomal enzyme inducer (MEI), phenobarbital (PB), has been proposed to promote thyroid tumors by increasing the biotransformation and elimination of T4, resulting in an increase in serum thyroid-stimulating hormone (TSH). In turn, TSH stimulat
Publikováno v:
Toxicology and applied pharmacology. 188(1)
The microsomal enzyme inducers phenobarbital (PB), pregnenolone-16 alpha-carbonitrile (PCN), 3-methylcholanthrene (3MC), and Aroclor 1254 (PCB) are known to induce thyroxine (T(4)) glucuronidation and reduce serum T(4) concentrations in rats. Also, m
Autor:
Curtis D. Klaassen, Alan M. Hood
Publikováno v:
Toxicology and applied pharmacology. 163(3)
Microsomal enzyme inducers, such as phenobarbital (PB), pregnenolone-16α-carbonitrile (PCN), 3-methylcholanthrene (3MC), and Aroclor 1254 (PCB) are more effective at reducing serum thyroxine (T 4 ) than serum triiodothyronine (T 3 ). It is possible