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Publikováno v:
Toxicology and Applied Pharmacology. 360:78-87
Various rodent models of statin-associated muscle symptoms (SAMS) have been used to investigate the aetiology of statin myotoxicity. Variability between these models, however, may be contributing to the ambiguity currently surrounding the pathogenesi
Autor:
Mahmoud M. El-Mas, Yasser H. Habib, Nevine M. El-Deeb, Sherien A. Abdelhady, Mennatallah A. Gowayed, Inas E. Darwish
Publikováno v:
Toxicology and applied pharmacology. 426
Current therapies for preeclampsia (PE) and its complications are limited and defective. Considering the importance of endothelin (ET) and thromboxane A2 (TXA2) signaling in PE pathophysiology, we tested the hypothesis that prenatal blockade of endot
Publikováno v:
Toxicology and applied pharmacology. 423
The expression of transporters on the apical and basal membranes of renal proximal tubular cells are down- or upregulated to various extents under cisplatin (CDDP)-induced acute kidney injury (AKI). However, little is known about the changes in trans
Publikováno v:
Toxicology and applied pharmacology. 396
High-fat high-fructose diet (HFF) in obesity can induce dyslipidemia and lipid accumulation both in kidney and liver which related to insulin resistance and lipotoxicity-induced cellular damage. We investigated whether dapagliflozin with or without a
Publikováno v:
Toxicology and Applied Pharmacology. 334:110-119
The endothelium-derived hyperpolarizing factor (EDHF) serves as a back-up mechanism that compensates for reduced nitric oxide (NO)/prostanoids bioavailability. Here we investigated whether (i) under conditions of vascular endothelium dysfunction, the
Autor:
Daniel Carpio, Andrés Aburto, Areli Cárdenas, Agustín Barría, María E. Burgos, Carlos D. Figueroa, Leopoldo Ardiles
Publikováno v:
TOXICOLOGY AND APPLIED PHARMACOLOGY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Antineoplastic treatment with cisplatin is frequently complicated by nephrotoxicity. Although oxidative stress may be involved, the pathogenic mechanisms responsible for renal damage have not been completely clarified. In order to investigate the rol
Publikováno v:
Toxicology and Applied Pharmacology. 279:1-7
Diabetic nepropathy (DN) is considered as the leading cause of end-stage renal disease (ESRD) worldwide, but the current available treatments are limited. Recent experimental evidences support the role of chronic microinflammation in the development
Publikováno v:
Toxicology and Applied Pharmacology. 275:88-95
Endothelin (ET) signaling provokes nephrotoxicity induced by the immunosuppressant drug cyclosporine A (CSA). We tested the hypotheses that (i): celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, counterbalances renal derangements caused by C
Autor:
Yu-Ming Kang, Qing Yang, Xiao-Jing Yu, Da-Nian Qin, Jie Qi, Qing Su, Guo-Qing Zhu, Li-Ying Yue, Dong-Mei Zhang, Yu-Ping Suo
Publikováno v:
Toxicology and Applied Pharmacology. 274:436-444
The renin-angiotensin system (RAS) in the brain is involved in the pathogenesis of hypertension. We hypothesized that inhibition of angiotensin-converting enzyme (ACE) in the hypothalamic paraventricular nucleus (PVN) attenuates angiotensin II (ANG I
Autor:
Reem N. El-Naga
Publikováno v:
Toxicology and Applied Pharmacology. 274:87-95
Cisplatin is an effective anti-cancer drug; however, its clinical use is usually associated with nephrotoxicity as a dose-limiting side effect. Several molecular mechanisms have been found to be involved in this nephrotoxicity such as oxidative stres