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Publikováno v:
Toxicology and Applied Pharmacology. 334:110-119
The endothelium-derived hyperpolarizing factor (EDHF) serves as a back-up mechanism that compensates for reduced nitric oxide (NO)/prostanoids bioavailability. Here we investigated whether (i) under conditions of vascular endothelium dysfunction, the
Autor:
Liang Xu, Cuiping Yang, Zheng Li, Tianhong Zhang, Keliang Liu, Fei Liu, Zhenqing Zhang, Jinxiu Ruan
Publikováno v:
Toxicology and Applied Pharmacology. 273:561-568
Aconitine (AC) is a highly toxic alkaloid from bioactive plants of the genus Aconitum, some of which have been widely used as medicinal herbs for thousands of years. In this study, we systematically evaluated the potential role of P-glycoprotein (P-g
Publikováno v:
Toxicology and Applied Pharmacology. 210:142-149
We previously reported that sequence of exposure to chlorpyrifos and parathion in adult rats can markedly influence toxic outcome. In the present study, we evaluated the interactive toxicity of chlorpyrifos (8 mg/kg, po) and parathion (0.5 mg/kg, po)
Autor:
David Pubill, Ester Verdaguer, Andrés Jiménez, Antoni Camins, Mercè Pallàs, Elvira G. Jordà, Elena Escubedo, Anna M. Canudas, Jordi Camarasa, Francesc X. Sureda
Publikováno v:
Toxicology and Applied Pharmacology. 196:223-234
The neurotoxic action of the abuse drugs methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA) on cerebellar granule neurones (CGNs) culture was examined. Treatment for 48 h with METH or MDMA (1-5 mM) induced a higher decrease in viabil
Publikováno v:
Toxicology and Applied Pharmacology. 172:37-43
(-)-Deprenyl (DEP) had been shown to slow of progression of Parkinson's disease (PD). The present study sought to determine whether DEP would attenuate the nigrostriatal system damage induced by intranigral administration of the herbicide paraquat (P
Publikováno v:
Toxicology and Applied Pharmacology. 164:176-183
Acrolein, an unsaturated aliphatic aldehyde, is a potent respiratory irritant. We have previously observed that acrolein administered ex vivo to isolated airways alters subsequent airway responsiveness to muscarinic agonists in terms of both mechanic
Publikováno v:
Toxicology and Applied Pharmacology. 158:115-124
The purpose of the present study was to investigate the contribution of lysosomal trapping to the total tissue uptake of thioridazine and to potential drug distribution interactions between thioridazine and tricyclic antidepressants (imipramine, amit
Autor:
Elizabeth H. Jeffery, William J. Bement, Jacqueline F. Sinclair, Peter R. Sinclair, Vsevolod E. Kostrubsky, Sheryl G. Wood, Steven A. Wrighton, Juliana G. Szakacs
Publikováno v:
Toxicology and Applied Pharmacology. 143:315-323
CYP2E is considered the only form of cytochrome P450 responsible for ethanol-mediated increases in acetaminophen hepatotoxicity. However, in experimental systems used for investigating ethanol-mediated increases in acetaminophen hepatotoxicity, anima
Publikováno v:
Toxicology and Applied Pharmacology. 130:237-247
Environmental and occupational exposures are typically to mixtures of chemicals, although most toxicity information is for individual compounds. Interactions between chemicals may involve pharmacokinetic and/or pharmacodynamic effects resulting in mo
Publikováno v:
Toxicology and applied pharmacology. 265(2)
Methamphetamine (METH) is a drug of abuse which causes neurotoxicity and increased risk of developing neurodegenerative diseases. We previously found that METH induces heme oxygenase (HO)-1 expression in neurons and glial cells, and this offers parti