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Autor:
Jinyi Zhou, Juanjuan Liang, Xintong Yan, Shuai Lu, Baolin Jiang, Xiaowen Bi, Lan Luo, Jie Liu, Zhimin Yin
Publikováno v:
Toxicology and applied pharmacology. 433
Indoprofen is a non-steroidal anti-inflammatory drug, and has provided insights into treatment of spinal muscular atrophies; however, the treatment effect of indoprofen on sepsis and the precise underlying mechanism remain to be elucidated. This stud
Autor:
Francesca Romana Gallo, Maria Condello, Evelin Pellegrini, Stefania Meschini, Francesca Zazzeroni, Davide Vecchiotti, Giuseppina Multari
Publikováno v:
Toxicology and applied pharmacology. 434
Most women with ovarian cancer are treated with chemotherapy before or after surgery. Unfortunately, chemotherapy treatment can cause negative side effects and the onset of multidrug resistance (MDR). The aim of this study is to evaluate the chemosen
Autor:
Zuoxian Lin, Feng Tang, Yili Chen, Jian Hou, Zhiyuan Li, Long Yan, Zhongkai Wu, Xiaolin Huang, Wei Li
Publikováno v:
Toxicology and applied pharmacology. 431
Benzethonium chloride (BZT) and domiphen bromide (DMP) are widely used as antimicrobials in drugs, vaccines and industry. However, no cardiac safety data has been developed on both compounds. Previously we reported BZT and DMP as high-affinity human
Autor:
Yi-xuan Sun, An-mei Wang, Ailin Yang, Xiu-lian Li, Shaoping Wang, Yu-fan Tao, Zhong-dong Hu, Qi Wu, Jiayu Zhang, Long Dai
Publikováno v:
Toxicology and applied pharmacology. 431
Hepatocellular carcinoma (HCC) is one of the deadliest cancers with high mortality and poor prognosis, and the investigation on new approaches and effective drugs for HCC therapy is of great significance. In our study, we demonstrate that treatment w
Autor:
Mahmoud M. El-Mas, Yasser H. Habib, Nevine M. El-Deeb, Sherien A. Abdelhady, Mennatallah A. Gowayed, Inas E. Darwish
Publikováno v:
Toxicology and applied pharmacology. 426
Current therapies for preeclampsia (PE) and its complications are limited and defective. Considering the importance of endothelin (ET) and thromboxane A2 (TXA2) signaling in PE pathophysiology, we tested the hypothesis that prenatal blockade of endot
Publikováno v:
Toxicology and applied pharmacology. 423
The expression of transporters on the apical and basal membranes of renal proximal tubular cells are down- or upregulated to various extents under cisplatin (CDDP)-induced acute kidney injury (AKI). However, little is known about the changes in trans
Publikováno v:
Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2019, 375, pp.46-56. ⟨10.1016/j.taap.2019.05.002⟩
Toxicology and Applied Pharmacology, Elsevier, 2019, 375, pp.46-56. ⟨10.1016/j.taap.2019.05.002⟩
Our previous studies showed that prenatal ethanol exposure (PEE) elevated blood total cholesterol (TCH) level in adult offspring rats. This study was aimed at elucidating the intrauterine programming mechanism of hypercholesterolemia in adult rats in
Publikováno v:
Toxicology and Applied Pharmacology. 370:145-153
Methamphetamine (METH) is a highly addictive stimulant and METH exposure can induce a series of neuroinflammatory effects. Peli1 is a novel and important E3 ubiquitin-protein ligase contributing to neuroinflammation; targeting Peli1 may thus provide
Publikováno v:
Toxicology and Applied Pharmacology. 368:18-25
In spite of remarkable reduction in the number of children born with HIV due to antiretroviral therapy, concerns remain on the short- and long-term effects of antiretroviral drugs at the feto-placental unit. Cardio- and skeletal myopathies have been
Autor:
Chongyao Li, Xu Yang, Biao Yan, Jie Zeng, Yang Wu, Lin Zhang, Ping Ma, Yingying Chen, Yanling Sun, Peng Song
Publikováno v:
Toxicology and Applied Pharmacology. 368:1-17
Learning disabilities (LDs) in children are a serious global problem. Dibutyl phthalate (DBP), a plasticizer widely used in daily life, has been linked to triggering childhood LDs, however the mechanism underlying this remains unclear. Studies have s