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Autor:
Xinghui Wang, Chenxing Li, Hao Hu, Lina Chen, Baode Yang, Chun Yang, Junyi Sun, Xinling Liu, Jun Zhou
Publikováno v:
Toxicology and Applied Pharmacology. 322:89-96
Excessive consumption of alcohol is a well-established risk factor of atrial fibrillation (AF). However, the effects of moderate alcohol drinking remain to be elucidated. This study was designed to determine the effects of moderate ethanol ingestion
Publikováno v:
Toxicology and Applied Pharmacology. 322:97-103
Oxaliplatin use as chemotherapeutic agent is frequently limited by cumulative neurotoxicity which may compromise quality of life. Reports relate this neurotoxic effect to oxidative stress and mitochondrial dysfunction in peripheral nerves and dorsal
Autor:
Willem van den Brink, Francesco Bellanti, Jan Willem van der Laan, Annette Emerenciana, Oscar Della Pasqua
Publikováno v:
Toxicology and Applied Pharmacology. 320:51-59
Increased incidence of C-cell carcinogenicity has been observed for glucagon-like-protein-1 receptor (GLP-1r) agonists in rodents. It is suggested that the duration of exposure is an indicator of carcinogenic potential in rodents of the different pro
Publikováno v:
Toxicology and Applied Pharmacology. 319:12-21
Ciproxifan is an H3 receptor antagonist and inverse agonist with antipsychotic effects in several preclinical models; its effect on glutamate release has been investigated in the rat hippocampus. In a synaptosomal preparation, ciproxifan reduced 4-am
Autor:
S Arvinda, Dilip M. Mondhe, Jyotsna Suri, Gurdarshan Singh, Surinder Koul, Surjeet Singh, Ram A. Vishwakarma, Amarinder Singh
Publikováno v:
Toxicology and Applied Pharmacology. 318:8-15
The limiting factor for the use of Cisplatin in the treatment of different type of cancers is its toxicity and more specifically urogenital toxicity. Oxidative stress is a well-known phenomenon associated with Cisplatin toxicity. However, in Cisplati
Publikováno v:
Toxicology and Applied Pharmacology. 318:58-68
NLRP3 inflammasome activation occurs in response to hazardous particle exposures and is critical for the development of particle-induced lung disease. Mechanisms of Lysosome Membrane Permeabilization (LMP), a central pathway for activation of the NLR
Publikováno v:
Toxicology and Applied Pharmacology. 315:80-89
Loss of pericytes, considered an early hallmark of diabetic retinopathy, is thought to involve abnormal activation of protein kinase C (PKC). We previously showed that the anti-amyotrophic lateral sclerosis (ALS) drug riluzole functions as a PKC inhi
Autor:
J. Mlynarczuk, Michael Hubert Wrobel
Publikováno v:
Toxicology and Applied Pharmacology. 314:63-71
The aim of the study was to investigate the effect of chlordane, heptachlor and mirex, on hormonal regulation of the force of myometrial contractions. Myometrial, endometrial, granulosa and luteal cells as well as strips of myometrium from non-pregna
Autor:
Gwi Yeong Jang, Dongsun Park, Jeong-Yong Lee, Heon-Sang Jeong, Su Kil Jang, Yun-Bae Kim, Sang Hoon Lee, Haiyu Guo, Young-Hwan Ban, Sungho Yeon, Yeseul Cha, Ehn-Kyoung Choi, Seong Soo Joo
Publikováno v:
Toxicology and Applied Pharmacology. 314:48-54
This study investigated the effects of a silk peptide fraction obtained by incubating silk proteins with Protease N and Neutrase (SP-NN) on cognitive dysfunction of Alzheimer disease model rats. In order to elucidate underlying mechanisms, the effect
Autor:
Akinobu Shibata, Yuji Takekoshi, Naoko Okumura, Koichi Suenami, Akira Ikari, Yoshifumi Morikawa, Yasuhide Sasajima, Ossama El-Kabbani, Toshiyuki Matsunaga, Kiyohito Sato
Publikováno v:
Toxicology and Applied Pharmacology. 314:1-11
Overdose administration of sibutramine, a serotonin-noradrenalin reuptake inhibitor, is considered to elicit severe side effects including hypertension, whose pathogenic mechanism remains unclear. Here, we found that 48-h incubation with >10μM sibut