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Autor:
Richard A. Glennon, Iwona Ruchala, Jose M. Eltit, Rita Yu-Tzu Chen, Vy T. Nguyen, Umberto Maria Battisti
Publikováno v:
Toxicology and Applied Pharmacology. 419:115513
The early characterization of ligands at the dopamine and serotonin transporters, DAT and SERT, respectively, is important for drug discovery, forensic sciences, and drug abuse research. 4-Methyl amphetamine (4-MA) is a good example of an abused drug
Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX
Publikováno v:
Toxicology and Applied Pharmacology. 419:115512
Nerve agents are highly toxic organophosphorus compounds that inhibit acetylcholinesterase resulting in rapid accumulation of the neurotransmitter acetylcholine (ACh) causing a cholinergic syndrome including respiratory failure. In the present study,
Autor:
Xin Liang, Xuan Huang, Yun Yang, Qianyi Gong, Changfeng Song, Xiaotong Wang, Jiaping Fang, Jianwen Liu
Publikováno v:
Toxicology and Applied Pharmacology. 418:115484
The clinical use of cisplatin are limited due to its drug resistance. Thus, it is urgent to find effective combination therapy that sensitizes tumor cells to this drug. The combined chemo-photodynamic therapy could increase anti-tumor efficacy while
Publikováno v:
Toxicology and Applied Pharmacology. 416:115466
Soman, an organophosphorus (OP) compound, disrupts nervous system function through inactivation of acetylcholinesterase (AChE), the enzyme that breaks down acetylcholine at synapses. Left untreated, a state of prolonged seizure activity (status epile
Autor:
Bárbara Silva, Andreia Palmeira, Paula Guedes de Pinho, Fernando Remião, Carla Fernandes, Renata Silva
Publikováno v:
Toxicology and Applied Pharmacology. 416:115442
Cathinone derivatives are the most representative group within new drugs market, which have been described as neurotoxic. Since cathinones, as pentedrone and methylone, are available as racemates, it is our aim to study the neuronal cytotoxicity indu
Autor:
Fellype C. Barreto, Julia Budag, Maria Dolores Sanchez-Niño, Alberto Ortiz, Regiane Stafim da Cunha, Gilson Biagini, PauloC. Gregório, Bruna Bosquetti, Andréa E.M. Stinghen
Publikováno v:
Toxicology and Applied Pharmacology
COVID-19 is a pandemic with no end in sight. There is only one approved antiviral agent but global stocks are deemed insufficient. Despite in vitro antiviral activity, clinical trials of chloroquine and hydroxychloroquine were disappointing, and they
Publikováno v:
Toxicology and Applied Pharmacology. 415:115443
The brain is a critical target for the toxic action of organophosphorus (OP) inhibitors of acetylcholinesterase (AChE) such as the nerve agent sarin. However, the available oxime antidote 2-PAM only reactivates OP-inhibited AChE in peripheral tissues
Autor:
Fengcui Sun, Chaoqun Ma, Jingjing Shi, Haifei Lu, Fengxia Zhang, Li Ruoqi, Lu Yu, Yantong Yu, Shizhao Zhang, Xiufen Yang
Publikováno v:
Toxicology and Applied Pharmacology. 412:115388
Phytosterol diosgenin (DG) exhibits cholesterol-lowering properties. Few studies focused on the underlying mechanism of DG attenuation of hypercholesterolemia by promoting cholesterol metabolism. To investigate the roles of SRB1/CES-1/CYP7A1/FXR path
Autor:
Manisha Patel, Jie Huang, Li-Ping Liang, Brian J. Day, Jennifer N. Pearson-Smith, Ruth Fulton
Publikováno v:
Toxicology and Applied Pharmacology. 326:34-42
Reactive oxygen species are a well-defined therapeutic target for Parkinson’s disease (PD) and pharmacological agents that catalytically scavenge reactive species are promising neuroprotective strategies for treatment. Metalloporphyrins are synthet
Publikováno v:
Toxicology and Applied Pharmacology. 324:26-35
Glucocorticoid-induced osteoporosis (GIO) is one of the most common causes of secondary osteoporosis. Given that glucocorticoids are considered as a main component of the treatment protocols for a variety of inflammation and immune-mediated diseases