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Autor:
Robert L. Tanguay, Sean M. Bugel
Publikováno v:
Toxicology and Applied Pharmacology. 344:23-34
The comparative analysis of complex behavioral phenotypes is valuable as a reductionist tool for both drug discovery and defining chemical bioactivity. Flavonoids are a diverse class of chemicals that elicit robust neuroactive and hormonal actions, t
Publikováno v:
Toxicology and Applied Pharmacology. 342:31-38
Air pollution is associated with increased incidence of metabolic disease (e.g. metabolic syndrome, obesity, diabetes); however, underlying mechanisms are poorly understood. Air pollutants increase the release of stress hormones (human cortisol, rode
Autor:
Francisco Fábio Bezerra de Oliveira, Anamaria Falcão Pereira, Bruno Wesley de Freitas Alves, Mario Roberto Pontes Lisboa, Mariana Lima Vale, Kalina Kelma Oliveira de Sousa, Karoline Luanne Santos de Menezes, Aline Kelly Viana de Mesquita
Publikováno v:
Toxicology and Applied Pharmacology. 340:77-84
Studies suggest that oxalate is involved in the development oxaliplatin-induced peripheral sensory neuropathy (OPSN). This study aimed to compare the neurotoxic effects of oxaliplatin with its oxalate-free cytotoxic analogue cis-[PtII(1R,2R-DACH)(3-a
Publikováno v:
Toxicology and Applied Pharmacology. 338:1-8
Abuse of synthetic cannabinoids is a serious social problem worldwide. Intentional ingestion of synthetic cannabinoids can cause severe toxicity, including seizures. Here we investigated the effects of acute administration of synthetic cannabinoids o
Adrenergic and glucocorticoid receptor antagonists reduce ozone-induced lung injury and inflammation
Autor:
Kevin Mauge-Lewis, Andres R. Henriquez, Mette C. Schladweiler, Colette N. Miller, Urmila P. Kodavanti, Allen D. Ledbetter, Marie A. McGee, Judy E. Richards, Janice A. Dye, Samantha J. Snow
Publikováno v:
Toxicology and Applied Pharmacology. 339:161-171
Recent studies showed that the circulating stress hormones, epinephrine and corticosterone/cortisol, are involved in mediating ozone-induced pulmonary effects through the activation of the sympathetic-adrenal-medullary (SAM) and hypothalamus-pituitar
Autor:
Seth Gibbs, Heather Toy, Natalie L. South, Suramya Waidyanatha, Esra Mutlu, Natasha R. Catlin, Brian L. Burback, Barry S. McIntyre
Publikováno v:
Toxicology and Applied Pharmacology. 338:83-92
Vinpocetine is being used worldwide by people of all ages, including pregnant women, for its purported multiple health benefits. However, limited data is available addressing the safety/toxicity of vinpocetine. The National Toxicology Program conduct
Autor:
Le An, Jonathan Maher, Yingqing Ran, Ryan E. Morgan, Lisa Wong, Laurent Salphati, Leah Schutt, Xiaolin Zhang, David Potter, Steven Cepa, Jacqueline M. Tarrant, Jodie Pang, Roxanne Andaya
Publikováno v:
Toxicology and Applied Pharmacology. 338:204-213
Drug-induced liver injury (DILI) has been the most frequent cause of post-marketing drug withdrawals in the last 50years. The multifactorial nature of events that precede severe liver injury in human patients is difficult to model in rodents due to a
Autor:
Peifen Cai, Qiang Xu, Jiashu Yang, Lingyan Xu, Yanhong Gu, Xiaofei Li, Xiaohan Wu, Wen Liu, Jian Gao, Wenjie Guo
Publikováno v:
Toxicology and Applied Pharmacology. 428:115672
5-Fluorouracil (5-FU)-based chemotherapy is the first-line recommended regimen in colorectal cancer (CRC), but resistance limits its clinical application. Andrographolide sulfonate, a traditional Chinese medicine, is mainly used to treat infectious d
Autor:
Lexiao Jin, Aruni Bhatnagar, Zhengzhi Xie, Sanjay Srivastava, Daniel J. Conklin, Pawel Lorkiewicz
Publikováno v:
Toxicol Appl Pharmacol
Acrolein, an electrophilic α,β-unsaturated aldehyde, is present in foods and beverages, and is a product of incomplete combustion, and thus, reaches high ppm levels in tobacco smoke and structural fires. Exposure to acrolein is linked with cardiopu
Autor:
J. Mlynarczuk, Michael Hubert Wrobel
Publikováno v:
Toxicology and Applied Pharmacology. 427:115667
Dichlorodiphenyltrichloroethane (DDT) is a representative organochlorine insecticide and a known endocrine disruptor. Malathion is an organophosphate insecticide and a next-generation pesticide. Previously, it was shown that oxytocin (OT) and prostag