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Autor:
Jinyi Zhou, Juanjuan Liang, Xintong Yan, Shuai Lu, Baolin Jiang, Xiaowen Bi, Lan Luo, Jie Liu, Zhimin Yin
Publikováno v:
Toxicology and applied pharmacology. 433
Indoprofen is a non-steroidal anti-inflammatory drug, and has provided insights into treatment of spinal muscular atrophies; however, the treatment effect of indoprofen on sepsis and the precise underlying mechanism remain to be elucidated. This stud
Autor:
Zuoxian Lin, Feng Tang, Yili Chen, Jian Hou, Zhiyuan Li, Long Yan, Zhongkai Wu, Xiaolin Huang, Wei Li
Publikováno v:
Toxicology and applied pharmacology. 431
Benzethonium chloride (BZT) and domiphen bromide (DMP) are widely used as antimicrobials in drugs, vaccines and industry. However, no cardiac safety data has been developed on both compounds. Previously we reported BZT and DMP as high-affinity human
Publikováno v:
Toxicology and applied pharmacology. 423
The expression of transporters on the apical and basal membranes of renal proximal tubular cells are down- or upregulated to various extents under cisplatin (CDDP)-induced acute kidney injury (AKI). However, little is known about the changes in trans
Publikováno v:
Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2019, 375, pp.46-56. ⟨10.1016/j.taap.2019.05.002⟩
Toxicology and Applied Pharmacology, Elsevier, 2019, 375, pp.46-56. ⟨10.1016/j.taap.2019.05.002⟩
Our previous studies showed that prenatal ethanol exposure (PEE) elevated blood total cholesterol (TCH) level in adult offspring rats. This study was aimed at elucidating the intrauterine programming mechanism of hypercholesterolemia in adult rats in
Publikováno v:
Toxicology and Applied Pharmacology. 370:145-153
Methamphetamine (METH) is a highly addictive stimulant and METH exposure can induce a series of neuroinflammatory effects. Peli1 is a novel and important E3 ubiquitin-protein ligase contributing to neuroinflammation; targeting Peli1 may thus provide
Autor:
Chongyao Li, Xu Yang, Biao Yan, Jie Zeng, Yang Wu, Lin Zhang, Ping Ma, Yingying Chen, Yanling Sun, Peng Song
Publikováno v:
Toxicology and Applied Pharmacology. 368:1-17
Learning disabilities (LDs) in children are a serious global problem. Dibutyl phthalate (DBP), a plasticizer widely used in daily life, has been linked to triggering childhood LDs, however the mechanism underlying this remains unclear. Studies have s
Autor:
Sérgio Henrique Sousa Santos, Thiago Roberto Lima Romero, Renata Cristina Mendes Ferreira, Marina G. M. Castor, Igor D.G. Duarte, Ághata de França Costa, Luciano dos Santos Aggum Capettini, Juliana Maria Navia Pelaez, Virginia S. Lemos, Camila Gomes Miranda e Castor, Josiane F. Silva, Andrea de Castro Perez, Cristina da Costa Oliveira
Publikováno v:
Toxicology and Applied Pharmacology. 369:30-38
Despite all the development of modern medicine, around 100 compounds derived from natural products were undergoing clinical trials only at the end of 2013. Among these natural substances in clinical trials, we found the resveratrol (RES), a pharmacol
Publikováno v:
Toxicology and Applied Pharmacology. 367:36-50
Pulmonary exposure to silver nanoparticles (AgNPs) revealed the potential of nanoparticles to cause pulmonary toxicity, cross the alveolar-capillary barrier, and distribute to remote organs. However, the mechanism underlying the effects of AgNPs on t
Autor:
Kelie Chen, Hanwen Chen, Yihua Wu, Hao Yang, Yufeng Qian, Peiwei Li, Hui Lin, Shujun Xie, Jianting Cai, Dajing Xia, Han-Ming Shen, Jianhang Leng, Yuequn Niu, Bo Huang
Publikováno v:
Toxicology and Applied Pharmacology. 365:19-29
Myricetin is a plant-derived flavonoid that exhibits diverse pharmacological properties. The NLRP3 (NLR family, pyrin domain-containing 3 protein) inflammasome is a cytosolic multiprotein complex that plays a critical role in the innate immune respon
Autor:
Fan Jiaojiao, Qiugen Wang, Chi Zhang, Haipeng Liang, Zizheng Wu, Jian Gao, Chunlin Li, Qi Wang
Publikováno v:
Toxicology and Applied Pharmacology. 362:20-27
Aluminum (Al) recognized as a persistent environmental contaminant is associated with bone diseases. Nicotinamide mononucleotide (NMN) is an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis widely used to replenish NAD+. Increasi