Zobrazeno 1 - 10
of 133
pro vyhledávání: ''
Autor:
Fan Jiaojiao, Qiugen Wang, Chi Zhang, Haipeng Liang, Zizheng Wu, Jian Gao, Chunlin Li, Qi Wang
Publikováno v:
Toxicology and Applied Pharmacology. 362:20-27
Aluminum (Al) recognized as a persistent environmental contaminant is associated with bone diseases. Nicotinamide mononucleotide (NMN) is an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis widely used to replenish NAD+. Increasi
Publikováno v:
Toxicology and applied pharmacology. 423
The expression of transporters on the apical and basal membranes of renal proximal tubular cells are down- or upregulated to various extents under cisplatin (CDDP)-induced acute kidney injury (AKI). However, little is known about the changes in trans
Autor:
Tseela David, Shlomi Lazar, Shlomi Baranes, Inbal Egoz, Michael Yampolsky, Ettie Grauer, Rellie Gez, Hani Dekel Jaoui, Adi Neufeld-Cohen, Rahav Efrati, Ariel Gore, Shira Chapman
Publikováno v:
Toxicology and applied pharmacology. 419
The development of refractory status epilepticus (SE) induced by sarin intoxication presents a therapeutic challenge. In our current research we evaluate the efficacy of a delayed combined triple treatment in ending the abnormal epileptiform seizure
Autor:
Li Chen, Pan Lei, Wei Lu, Yonghong Zhang, Tao Zheng, Fang Bian, Qibin Wang, Xincai Hao, Yan Zhao, Lulu Zhang, Weidong Ma
Publikováno v:
Toxicology and applied pharmacology. 416
High glucose (HG)-induced nucleotide-binding and oligomerization (NACHT) domain, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3 (NLRP3) inflammasome activation leads to diabetic neuropathic pain. We recently showed that salidr
Autor:
Adi Neufeld-Cohen, Shlomi Baranes, Ariel Gore, Shira Chapman, Ettie Grauer, Shlomi Lazar, Inbal Egoz, Rellie Gez
Publikováno v:
Toxicology and applied pharmacology. 395
Background Sarin is an irreversible organophosphate cholinesterase inhibitor. Following toxic signs, an extensive long-term brain damage is often reported. Thus, we evaluated the efficacy of a novel anticonvulsant drug retigabine, a modulator of neur
Autor:
Le An, Jonathan Maher, Yingqing Ran, Ryan E. Morgan, Lisa Wong, Laurent Salphati, Leah Schutt, Xiaolin Zhang, David Potter, Steven Cepa, Jacqueline M. Tarrant, Jodie Pang, Roxanne Andaya
Publikováno v:
Toxicology and Applied Pharmacology. 338:204-213
Drug-induced liver injury (DILI) has been the most frequent cause of post-marketing drug withdrawals in the last 50years. The multifactorial nature of events that precede severe liver injury in human patients is difficult to model in rodents due to a
Publikováno v:
Toxicology and Applied Pharmacology. 334:110-119
The endothelium-derived hyperpolarizing factor (EDHF) serves as a back-up mechanism that compensates for reduced nitric oxide (NO)/prostanoids bioavailability. Here we investigated whether (i) under conditions of vascular endothelium dysfunction, the
Autor:
Jiao Zenghua, Ya-Jun Yang, Liu Xiwang, Peng-Cheng Dong, Isam Karam, Kong Xiaojun, Li Shihong, Ning Ma, Qin Zhe, Jianyong Li
Publikováno v:
Toxicology and Applied Pharmacology. 332:40-51
The main objective of this study was to investigate the ameliorative effects of aspirin eugenol ester (AEE) in hyperlipidemic rat. After five-week oral administration of AEE in high fat diet (HFD)-induced hyperlipidemic rats, the impact of AEE on pla
Publikováno v:
Toxicology and Applied Pharmacology. 416:115466
Soman, an organophosphorus (OP) compound, disrupts nervous system function through inactivation of acetylcholinesterase (AChE), the enzyme that breaks down acetylcholine at synapses. Left untreated, a state of prolonged seizure activity (status epile
Publikováno v:
Toxicology and Applied Pharmacology. 329:85-95
Naloxegol is an opioid antagonist which has been developed for the treatment of patients with opioid induced constipation. In the nonclinical safety program naloxegol was shown to have a very benign toxicity profile. In the rat, but not the mouse, 2-