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Autor:
Mahmoud M. El-Mas, Yasser H. Habib, Nevine M. El-Deeb, Sherien A. Abdelhady, Mennatallah A. Gowayed, Inas E. Darwish
Publikováno v:
Toxicology and applied pharmacology. 426
Current therapies for preeclampsia (PE) and its complications are limited and defective. Considering the importance of endothelin (ET) and thromboxane A2 (TXA2) signaling in PE pathophysiology, we tested the hypothesis that prenatal blockade of endot
Publikováno v:
Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2019, 375, pp.46-56. ⟨10.1016/j.taap.2019.05.002⟩
Toxicology and Applied Pharmacology, Elsevier, 2019, 375, pp.46-56. ⟨10.1016/j.taap.2019.05.002⟩
Our previous studies showed that prenatal ethanol exposure (PEE) elevated blood total cholesterol (TCH) level in adult offspring rats. This study was aimed at elucidating the intrauterine programming mechanism of hypercholesterolemia in adult rats in
Publikováno v:
Toxicology and Applied Pharmacology. 359:62-69
We investigated the potential effects of monosodium glutamate (MSG)-induced obesity with regards to nitric oxide and prostanoid production, as well as potassium channel function, in rat thoracic arteries. Newborn male Wistar rats were injected intrap
Publikováno v:
Toxicology and applied pharmacology. 396
High-fat high-fructose diet (HFF) in obesity can induce dyslipidemia and lipid accumulation both in kidney and liver which related to insulin resistance and lipotoxicity-induced cellular damage. We investigated whether dapagliflozin with or without a
Publikováno v:
Toxicology and Applied Pharmacology. 347:104-114
Numerous studies have demonstrated that short-term air pollution exposure causes cardiac autonomic imbalance as measured by heart rate variability (HRV). We previously showed that a single exposure to acrolein, a ubiquitous gaseous component of air p
Publikováno v:
Toxicology and Applied Pharmacology. 345:66-74
Cumulative evidence has suggested that many antipsychotics cause metabolic abnormalities. Adipose tissue insulin resistance (Adipo-IR) contributes to the development and progress of metabolic abnormalities including fatty liver by inducing excessive
Publikováno v:
Toxicology and Applied Pharmacology. 342:31-38
Air pollution is associated with increased incidence of metabolic disease (e.g. metabolic syndrome, obesity, diabetes); however, underlying mechanisms are poorly understood. Air pollutants increase the release of stress hormones (human cortisol, rode
Adrenergic and glucocorticoid receptor antagonists reduce ozone-induced lung injury and inflammation
Autor:
Kevin Mauge-Lewis, Andres R. Henriquez, Mette C. Schladweiler, Colette N. Miller, Urmila P. Kodavanti, Allen D. Ledbetter, Marie A. McGee, Judy E. Richards, Janice A. Dye, Samantha J. Snow
Publikováno v:
Toxicology and Applied Pharmacology. 339:161-171
Recent studies showed that the circulating stress hormones, epinephrine and corticosterone/cortisol, are involved in mediating ozone-induced pulmonary effects through the activation of the sympathetic-adrenal-medullary (SAM) and hypothalamus-pituitar
Autor:
Le An, Jonathan Maher, Yingqing Ran, Ryan E. Morgan, Lisa Wong, Laurent Salphati, Leah Schutt, Xiaolin Zhang, David Potter, Steven Cepa, Jacqueline M. Tarrant, Jodie Pang, Roxanne Andaya
Publikováno v:
Toxicology and Applied Pharmacology. 338:204-213
Drug-induced liver injury (DILI) has been the most frequent cause of post-marketing drug withdrawals in the last 50years. The multifactorial nature of events that precede severe liver injury in human patients is difficult to model in rodents due to a
Autor:
J. Mlynarczuk, Michael Hubert Wrobel
Publikováno v:
Toxicology and Applied Pharmacology. 427:115667
Dichlorodiphenyltrichloroethane (DDT) is a representative organochlorine insecticide and a known endocrine disruptor. Malathion is an organophosphate insecticide and a next-generation pesticide. Previously, it was shown that oxytocin (OT) and prostag