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Publikováno v:
Toxicology and Applied Pharmacology. 334:110-119
The endothelium-derived hyperpolarizing factor (EDHF) serves as a back-up mechanism that compensates for reduced nitric oxide (NO)/prostanoids bioavailability. Here we investigated whether (i) under conditions of vascular endothelium dysfunction, the
Publikováno v:
Toxicology and applied pharmacology. 379
Organic anion-transporting polypeptides (human OATPs; animals Oatps; gene symbol SLCO/Slco) are integral membrane proteins that mediate the sodium-independent transport of a wide range of endogenous compounds as well as many xenobiotics. Antibiotics,
Autor:
Liang Xu, Cuiping Yang, Zheng Li, Tianhong Zhang, Keliang Liu, Fei Liu, Zhenqing Zhang, Jinxiu Ruan
Publikováno v:
Toxicology and Applied Pharmacology. 273:561-568
Aconitine (AC) is a highly toxic alkaloid from bioactive plants of the genus Aconitum, some of which have been widely used as medicinal herbs for thousands of years. In this study, we systematically evaluated the potential role of P-glycoprotein (P-g
Publikováno v:
Toxicology and Applied Pharmacology. 266:452-458
It has been hypothesized in the literature that intake of high-dosage vitamin E supplements might alter the expression of cytochrome P(450) enzymes (CYP), particularly CYP3A4, which may lead to adverse nutrient-drug interactions. Because previously p
Publikováno v:
Toxicology and Applied Pharmacology. 256:360-368
Some published studies suggest that low level exposure to organophosphorus esters (OPs) may cause neurological and neurobehavioral effects at long term exposure. These effects cannot be explained by action on known targets. In this work, the interact
Publikováno v:
Toxicology and Applied Pharmacology. 210:142-149
We previously reported that sequence of exposure to chlorpyrifos and parathion in adult rats can markedly influence toxic outcome. In the present study, we evaluated the interactive toxicity of chlorpyrifos (8 mg/kg, po) and parathion (0.5 mg/kg, po)
Autor:
David Pubill, Ester Verdaguer, Andrés Jiménez, Antoni Camins, Mercè Pallàs, Elvira G. Jordà, Elena Escubedo, Anna M. Canudas, Jordi Camarasa, Francesc X. Sureda
Publikováno v:
Toxicology and Applied Pharmacology. 196:223-234
The neurotoxic action of the abuse drugs methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA) on cerebellar granule neurones (CGNs) culture was examined. Treatment for 48 h with METH or MDMA (1-5 mM) induced a higher decrease in viabil
Publikováno v:
Toxicology and Applied Pharmacology. 181:164-173
The cause of the Gulf War Syndrome may be related to soldiers being exposed to insecticides (e.g., permethrin (P)), insect repellents (e.g., N,N-diethyl-m-toluamide (DEET)), an organophosphate nerve agent simulant (e.g., diisopropyl fluorpohosphate (
Publikováno v:
Toxicology and Applied Pharmacology. 172:37-43
(-)-Deprenyl (DEP) had been shown to slow of progression of Parkinson's disease (PD). The present study sought to determine whether DEP would attenuate the nigrostriatal system damage induced by intranigral administration of the herbicide paraquat (P
Publikováno v:
Toxicology and Applied Pharmacology. 169:33-39
Sulfur mustard (SM) is a powerful vesicant employed as an agent of chemical warfare. This study demonstrates the therapeutic effect of a novel topical iodine preparation as a postexposure treatment against SM-induced lesions in the fur-covered guinea