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Publikováno v:
Toxicology and applied pharmacology. 217(2)
The present cell culture study investigated the effect of Ginkgo biloba extract pretreatment on acetaminophen toxicity and assessed the role of ginkgolide A and cytochrome P450 3A (CYP3A) in hepatocytes isolated from adult male Long-Evans rats provid
Autor:
Trisha L. Noreault-Conti, Jacqueline F. Sinclair, Steven A. Wrighton, Heidi W. Trask, Ralph C. Nichols, Judith M. Jacobs
Publikováno v:
Toxicology and applied pharmacology. 217(3)
Previous work in our laboratory has shown that acute exposure of primary rat hepatocyte cultures to non-toxic concentrations of arsenite causes major decreases in the DEX-mediated induction of CYP3A23 protein, with minor decreases in CYP3A23 mRNA. To
Publikováno v:
Toxicology and applied pharmacology. 206(1)
Nicotine and chlorpyrifos are developmental neurotoxicants that, despite their differences in structure and mechanism of action, share many aspects for damage to the developing brain. Both are thought to generate oxidative radicals; in the current st
Publikováno v:
Toxicology and applied pharmacology. 196(2)
The acute interactive toxicity following exposure to two common organophosphorus (OP) insecticides, chlorpyrifos (CPF) and methyl parathion (MPS), was investigated in adult male rats. Oral LD1 values were estimated by dose–response studies (CPF = 8
Publikováno v:
Toxicology and applied pharmacology. 177(1)
Several nicotinic agonists with the 6-chloro-3-pyridinyl moiety are potent insecticides (e.g., the neonicotinoids imidacloprid and thiacloprid) while others are candidate nonopioid and nonantiinflammatory analgesics (i.e., epibatidine and several het
Autor:
F. Antonicelli, E.M. Drost, Ken Donaldson, Jeffrey R. Thompson, R.T. Hay, D.A. Brown, Rodger Duffin, L.A. Jiménez, I. Rahman, William MacNee
Publikováno v:
Toxicology and applied pharmacology. 166(2)
Exposure to particulate air pollution (PM(10)) is associated with exacerbations of respiratory diseases and increased cardiopulmonary mortality. PM(10) induces lung inflammation in rats, which has been attributed to many factors, including the ultraf
Autor:
Haruko Futagawa, Hiroaki Takahashi
Publikováno v:
Toxicology and applied pharmacology. 165(1)
We investigated noncholinergic actions of 2-sec-butylphenyl N-methylcarbamate (BPMC) on the isolated rabbit thoracic aorta to help determine the mechanisms responsible for its unique toxicological properties, which are characterized by cardiovascular
Publikováno v:
Toxicology and applied pharmacology. 144(2)
Simultaneous exposure to DEET and permethrin was recently proposed to be associated with the “Gulf War Syndrome.” However, no studies have reported the percutaneous absorption of DEET and permethrin when applied simultaneously to the skin as a mi
Publikováno v:
Toxicology and applied pharmacology. 137(2)
Safingol [(2S,3S)-2-amino-1,3-octadecanediol], a sphingosine analog that inhibits protein kinase C, was developed to treat dermatoses and cancer. Preclinical toxicology studies performed to assess the effects of safingol showed that 6 weeks of dermal
Autor:
Adedapo O. Savage, Ricardo A. Brown
Publikováno v:
Toxicology and applied pharmacology. 136(1)
The purpose of this investigation was to determine the mechanism(s) underlying the vasorelaxant effects of acute versus chronic acetaldehyde (ACA) exposure, in particular, the role of intact endothelium on contractile responses of rat aortic ring seg