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Publikováno v:
Toxicology and applied pharmacology. 379
Organic anion-transporting polypeptides (human OATPs; animals Oatps; gene symbol SLCO/Slco) are integral membrane proteins that mediate the sodium-independent transport of a wide range of endogenous compounds as well as many xenobiotics. Antibiotics,
Publikováno v:
Toxicology and applied pharmacology. 177(1)
Several nicotinic agonists with the 6-chloro-3-pyridinyl moiety are potent insecticides (e.g., the neonicotinoids imidacloprid and thiacloprid) while others are candidate nonopioid and nonantiinflammatory analgesics (i.e., epibatidine and several het
Autor:
Adedapo O. Savage, Ricardo A. Brown
Publikováno v:
Toxicology and applied pharmacology. 136(1)
The purpose of this investigation was to determine the mechanism(s) underlying the vasorelaxant effects of acute versus chronic acetaldehyde (ACA) exposure, in particular, the role of intact endothelium on contractile responses of rat aortic ring seg
Publikováno v:
Toxicology and Applied Pharmacology. 84:464-469
The effect of cyanide on whole-brain calcium levels was determined in mice administered KCN and correlated with the neurotoxic signs manifested during acute cyanide poisoning. KCN (10 mg/kg, sc) significantly increased whole-brain total calcium level
Autor:
J.L. Stickney
Publikováno v:
Toxicology and applied pharmacology. 40(1)
The drug 1-α-acetylmethadol (LAAM) is a long-acting, orally effective narcotic agonist. It has been proposed as a replacement for methadone in the medical treatment of persons addicted to narcotic analgesics. The purpose of the present investigation
Autor:
Neil R. Ackerman
Publikováno v:
Toxicology and applied pharmacology. 41(2)
Δ 9 -THC has bronchodilator and antiasthmatic activity in humans. The current studies were undertaken in the guinea pig to determine if it were either a bronchial smooth muscle relaxant or an antagonist of one or more of the allergic mediators. Trac
Autor:
Kazuhisa Furuhama, Takeshi Onodera
Publikováno v:
Toxicology and applied pharmacology. 86(3)
Normal, acidotic, dehydrated, or unilaterally nephrectomized rats (Sprague-Dawley) were injected with gentamicin (80 mg/kg/day) alone or in combination with cefoxitin (2 g/kg/day), cephalothin (2 g/kg/day), or cephaloridine (1 g/kg/day) once daily fo