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Autor:
Xinghui Wang, Chenxing Li, Hao Hu, Lina Chen, Baode Yang, Chun Yang, Junyi Sun, Xinling Liu, Jun Zhou
Publikováno v:
Toxicology and Applied Pharmacology. 322:89-96
Excessive consumption of alcohol is a well-established risk factor of atrial fibrillation (AF). However, the effects of moderate alcohol drinking remain to be elucidated. This study was designed to determine the effects of moderate ethanol ingestion
Autor:
Yimin Shei, Catherine Tenn, Thomas W. Sawyer, Pierre Lecavalier, Andrew Burczyk, Cory Vair, Peggy Nelson, Stephen Bjarnason
Publikováno v:
Toxicology and Applied Pharmacology. 247:179-190
The effect of ionic environment on sulphur mustard (bis 2-chloroethyl sulphide; HD) toxicity was examined in CHO-K1 cells. Cultures were treated with HD in different ionic environments at constant osmolar conditions (320 mOsM, pH 7.4). The cultures w
Autor:
Ke Dong, Yuzhe Du, Zhiqi Liu, Yoshiko Nomura, Ningguang Luo, Bhupinder P. S. Khambay, Jung Eun Lee
Publikováno v:
Toxicology and Applied Pharmacology. 234:266-272
Pyrethroid insecticides are classified as type I or type II based on their distinct symptomology and effects on sodium channel gating. Structurally, type II pyrethroids possess an {alpha}-cyano group at the phenylbenzyl alcohol position, which is lac
Autor:
Tsu-Chun Emma Lin, Lih-Ann Li
Publikováno v:
Toxicology and Applied Pharmacology. 220:252-261
Giving human adrenocortical H295R cells 14 mM KCl for 24 h significantly induced not only aldosterone biosynthesis but also cortisol biosynthesis. Pre-treating the cells with polychlorinated biphenyl 126 (PCB126) further increased potassium-induced a
Publikováno v:
Toxicology and Applied Pharmacology. 217:216-224
Introduction: Consumption of carbonated soft drinks has been shown to be independently associated with the development of overactive bladder symptoms (OR 1.62, 95% CI 1.18, 2.22) [Dallosso, H.M., McGrother, C.W., Matthews, R.J., Donaldson, M.M.K., 20
Autor:
Yoshikazu Miura, Hisao Matsui
Publikováno v:
Toxicology and Applied Pharmacology. 174:1-9
Oral administration of triphenyltin chloride (TPT) (60 mg/kg body wt) inhibits insulin secretion by perturbing the cytoplasmic Ca(2+) concentration ([Ca(2+)]i) in pancreatic beta-cells of the hamster. To test the possibility that the abnormal levels
Autor:
Hong Wang, Shang-wei Ma, Yan Zhu, Guanwei Fan, Zi-chang Niu, Xiumei Gao, Han Zhang, Haoping Mao, Yuefei Wang, Yan-Tong Xu
Publikováno v:
Toxicology and applied pharmacology. 274(1)
Excess or deficiency of catecholamine (CA) secretion was related with several diseases. Recently, estrogen and phytoestrogens were reported to regulate the activity of CA system. Bakuchiol is a phytoestrogen isolated from the seeds of Psoralea coryli
Autor:
Phillip S. Mushlin, Michael Fill, Xuande Li, Barry J. Cusack, Robert J. Boucek, Philip Palade, Herve A. Gambliel, Susan E. Shadle, Richard D. Olson
Publikováno v:
Toxicology and Applied Pharmacology. 169:168-176
Cardiac effects of anthracyclines or their metabolites may include both the stimulation and inhibition of Ca(2+) release from sarcoplasmic reticulum. In this study, the ability of daunorubicin and its primary metabolite, daunorubicinol, to stimulate
Publikováno v:
Toxicology and Applied Pharmacology. 169:33-39
Sulfur mustard (SM) is a powerful vesicant employed as an agent of chemical warfare. This study demonstrates the therapeutic effect of a novel topical iodine preparation as a postexposure treatment against SM-induced lesions in the fur-covered guinea
Publikováno v:
Toxicology and Applied Pharmacology. 164:176-183
Acrolein, an unsaturated aliphatic aldehyde, is a potent respiratory irritant. We have previously observed that acrolein administered ex vivo to isolated airways alters subsequent airway responsiveness to muscarinic agonists in terms of both mechanic