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Autor:
Ron E. Baynes, James D. Brooks, Gui L. Qiao, Nancy A. Monteiro-Riviere, Patrick L. Williams, Jim E. Riviere
Publikováno v:
Toxicology and Applied Pharmacology. 141:473-486
Recently, attention has been directed to the risk assessment of cutaneous exposure to chemical mixtures rather than to only a single compound since this is the exposure scenario in the environment, residence, and work place. Using acetone or dimethyl
Publikováno v:
Toxicology and Applied Pharmacology. 55:501-513
Twenty-one chemicals, solutions, and mixtures with different degrees of recognized irritant potential to the human eye were tested in albino rabbit eyes at dose volumes of 0.003, 0.01, 0.03, and 0.1 ml. Materials were administered directly to the cen
Publikováno v:
Toxicology and Applied Pharmacology. 27:11-19
In rats exposed to mercuric chloride up to 14 weeks (0.5 mg/Hg/kg every second day, sc), mercury present in the kidney was bound predominantly to metallothionein. This was attributed to induction of biosynthesis, due to which the level of metallothio
Autor:
R.S. Parsons, A.J. Canty
Publikováno v:
Toxicology and Applied Pharmacology. 41:441-444
Intraperitoneal injection of diphenylmercury into rats results in a much higher initial concentration of mercury in the brain than that following injection of mercuric chloride or phenylmercuric acetate. The concentration in the brain then decreases,
Autor:
Curtis D. Klaassen
Publikováno v:
Toxicology and Applied Pharmacology. 33:356-365
The disappearance of 203 Hg from the plasma of rats and its excretion into bile was quantitated for 2 hr after the iv administration of 0.03, 0.1, 0.3, 1.0, and 3.0 mg Hg/kg as 203 mercuric chloride. The concentration of 203 Hg in the bile was usuall
Autor:
H. S. Nakaue, Donald R. Buhler
Publikováno v:
Toxicology and applied pharmacology. 35(2)
[14C]-hexachlorophene was applied to intact, clipped skins of adult rats in four different solvents and an aqueous detergent solution. As much as 55% of the applied radioactivity was absorbed through the skin in a 24-hr period. Dimethyl sulfoxide enh
Autor:
Roger T. Snowden, Laszlo Magos
Publikováno v:
Toxicology and applied pharmacology. 60(3)
Rats made anorexic by methylmercury treatment preferred aqueous, 2,3-dimercaptosuccinic acid (2.5 mg DMSA/ml) to tap water. Food and fluid consumption or the clearance of mercury increased approximately to the same extent when both aqueous DMSA and t
Publikováno v:
Toxicology and applied pharmacology. 42(3)
Brook trout were exposed to experimental water concentrations of methylmercuric chloride at concentrations from 0.01 to 2.93 μ g of Hg/liter, to cadmium chloride from 0.06 to 6.35 μ g of Cd/liter, and to lead nitrate from 0.90 to 474 μ g of Pb/lit
Publikováno v:
Toxicology and applied pharmacology. 13(2)
Ethylmercuric chloride (EMC) labeled with 203Hg was administered to rats, and the chemical nature of the mercury compound which accumulated in the blood was investigated. More than 97% of the total mercury in the blood of the EMC-treated rats was ext