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Publikováno v:
Toxicology and applied pharmacology. 345
Pulmonary fibrosis is a chronic progressive disease with unknown etiology and has poor prognosis. Polyhexamethyleneguanidine phosphate (PHMG-P) causes acute interstitial pneumonia and pulmonary fibrosis in humans when it exposed to the lung. In a pre
Autor:
Hui Wang, Fangfang Duan, Zheng He, Chao Yuan, Guanghui Chen, Jinzhi Zhang, Chunjiang He, Hegui Huang, Yanyan Liu
Publikováno v:
Toxicology and applied pharmacology. 341
Our previous study proposed a glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming mechanism for prenatal caffeine exposure (PCE)-induced adrenal developmental dysfunction. Here, we focused on PCE-induced cell proliferation changes
Autor:
Jie Ping, Dan Xu, Lian Liu, Zheng He, Lu Ma, Hui Wang, Zixin Deng, Hao Kou, Hanwen Luo, Liaobin Chen, Lang Shen
Publikováno v:
Toxicology and Applied Pharmacology. 274:383-392
Our previous studies have demonstrated that prenatal caffeine ingestion induces an increased susceptibility to metabolic syndrome with alterations of glucose and lipid metabolic phenotypes in adult first generation (F1) of intrauterine growth retarda
Autor:
Nadia M. Hamdy, Ebtehal El-Demerdash
Publikováno v:
Toxicology and Applied Pharmacology. 261:292-299
Portal hypertension is a common complication of chronic liver diseases associated with liver fibrosis and cirrhosis. At present, beta-blockers such as carvedilol remain the medical treatment of choice for protection against variceal bleeding and othe
Autor:
Deborah K. Hansen, Nysia I. George, Ali Abdel-Rahman, Linda S. Pellicore, Daniel S. Fabricant, Gene E. White
Publikováno v:
Toxicology and Applied Pharmacology. 261:236-247
Background Since ephedra-containing dietary supplements were banned from the US market, manufacturers changed their formulations by eliminating ephedra and replacing with other botanicals, including Citrus aurantium , or bitter orange. Bitter orange
Autor:
N.R. Kelley, J.E. Schwartz, Michael F. Stone, Mark Schultz, Robyn B. Lee, Lore K. Wright, Mark C Moffett, Lucille A. Lumley
Publikováno v:
Toxicology and Applied Pharmacology. 259:376-386
Therapy of seizure activity following exposure to the nerve agent soman (GD) includes treatment with the anticonvulsant diazepam (DZP), an allosteric modulator of γ-aminobutyric acid A (GABA(A)) receptors. However, seizure activity itself causes the
Autor:
Ethery Amari, Magnus M. Che, Michele Conti, Soma Chanda, Bhupendra P. Doctor, Richard K. Gordon, Peter Rezk, Megan Boylan, Praveena Sabnekar, Madhusoodana P. Nambiar, Alfred M. Sciuto
Publikováno v:
Toxicology and Applied Pharmacology. 239:251-257
We evaluated the protective efficacy of nasal atropine methyl bromide (AMB) which does not cross the blood-brain barrier against sarin inhalation exposure. Age and weight matched male guinea pigs were exposed to 846.5 mg/m(3) sarin using a microinsti
Publikováno v:
Toxicology and Applied Pharmacology. 226:84-93
Streptozotocin (STZ) is a naturally occurring compound isolated from Streptomyces achromogens. It is used extensively for inducing diabetes in experimental animals. Diabetes mellitus is known to have proven adverse effects on male sexual organs and t
Publikováno v:
Toxicology and applied pharmacology. 288(1)
Fetal adrenal developmental status is the major determinant of fetal tissue maturation and offspring growth. We have previously proposed that prenatal ethanol exposure (PEE) suppresses fetal adrenal corticosterone (CORT) synthesis. Here, we focused o
Autor:
Akira Yasutake, Akinori Shimada, Tadashi Okawara, Yorishige Imamura, Hideaki Shimada, Morio Kiyozumi, Makiko Takahashi
Publikováno v:
Toxicology and Applied Pharmacology. 202(1):59-67
The Long–Evans Cinnamon (LEC) rat is a mutant strain that accumulates excessive tissue copper (Cu) and models the clinical symptoms and biological features of Wilson's disease in humans. We compared the effects of three metal chelating agents, N -b