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Autor:
R.S. Alphin, J.W. Ward
Publikováno v:
Toxicology and Applied Pharmacology. 14:182-191
The anorexigenic effects of fenfluramine HC1 ( N -ethyl-α-methyl-3-trifluoromethylphenethylamine hydrochloride, Ponderex ® ), d -amphetamine SO 4 ( d -α-methylphenethylamine sulfate) and phenmetrazine HCl (3-methyl-2-phenylmorpholine hydrochloride
Publikováno v:
Toxicology and applied pharmacology. 93(2)
To exclude the possibility that changes in hepatotoxicity and biotransformation were induced by diabetogen administration, the influence of long-lasting experimental insulin-dependent diabetes on the activities of benzphetamine demethylase, styrene o
Publikováno v:
Toxicology and applied pharmacology. 67(1)
Twelve male subjects were given placebo or 160 mg propranolol, in divided doses, during a 24-hr period before drinking a beverage containing 0 or 50 ml ethanol/70 kg body weight. Tests designed to measure mental and motor performance were administere
Autor:
Paul E. Palm, Elsie P. Arnold, Charles J. Kensler, John C. Leyczek, Kenneth W. Teague, Peter C. Rachwall
Publikováno v:
Toxicology and applied pharmacology. 44(1)
Dilutions of fresh-brewed coffee, at 12.5, 25, and 50% resulting in caffeine intakes of approximately 9, 19, and 38 mg/kg/day, respectively, were consumed by female rats as their sole beverage for 5 weeks prior to mating, throughout gestation and, in
Publikováno v:
Toxicology and applied pharmacology. 44(1)
The effects of preexposure of female rats to Kepone on hepatic drugmetabolizing enzymes and several other parameters of the multifunction oxidase system were investigated. Animals were exposed to 0, 50, 100, and 150 ppm Kepone in the daily ration for
Autor:
Toshiaki Koizumi, Yasuhiro Yamane
Publikováno v:
Toxicology and applied pharmacology. 65(2)
The effect of molybdenum on the acute toxicity of mercuric chloride was examined. Rats that were given mercuric chloride alone (0.03 mmol/kg, once, sc) all died within 2 days after treatment. However, rats pretreated with sodium molybdate (1.24 mmol/
Publikováno v:
Toxicology and applied pharmacology. 33(3)
Megestrol acetate was administered orally to female beagle dogs for 4 yr at 0.01, 0.1, or 0.25 mg/kg/day. Chlormadinone acetate was given to a comparable group at 0.25 mg/kg. Decreased evidence of estrus was noted for all megestrol acetate and the ch
Autor:
Samson A. Chow, Lawrence J. Fischer
Publikováno v:
Toxicology and applied pharmacology. 84(2)
The susceptibility of fetal endocrine pancreas to the diabetogenic action of cyproheptadine was investigated. Cyproheptadine (5 or 11 mg/kg) or water (control) was given orally once daily to pregnant rats on Days 13.5–20.5 or on Days 19.5–20.5 of
Publikováno v:
Toxicology and applied pharmacology. 84(3)
To assess the potential influence of diet on theobromine (TBR) disposition and the development of TBR-induced thymic and testicular toxicity, male Sprague-Dawley rats were given the following diets ad libitum for 28 days: (1) semipurified (S); (2) co
Autor:
Klaus Thomsen, Ole Vendelin Olesen
Publikováno v:
Toxicology and applied pharmacology. 45(1)
The toxic effects of lithium on kidney function were examined in rats given 8 mmol per kg body weight (ip) of lithium chloride as a 150 m m solution once a day. After 2 to 4 days of lithium administration the animals had lost 10 to 20 g body weight.