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Publikováno v:
Toxicology and applied pharmacology. 288(1)
Fetal adrenal developmental status is the major determinant of fetal tissue maturation and offspring growth. We have previously proposed that prenatal ethanol exposure (PEE) suppresses fetal adrenal corticosterone (CORT) synthesis. Here, we focused o
Autor:
Kembra L. Howdeshell, F S vom Saal, Hui-ming Huang, Cynthia Besch-Williford, Rachel L. Ruhlen, Dennis B. Lubahn, J. K. Day, L. C. Alworth
Publikováno v:
Toxicology and Applied Pharmacology. 183:10-22
We examined the effects on female CD-1 mice of fetal exposure to low doses of the drug diethylstilbestrol (DES) (0.1 microg/kg/day) and the insecticide methoxychlor (MXC) (10 microg/kg/day) as well as 1000-fold higher doses: 100 microg/kg/day DES and
Publikováno v:
Toxicology and Applied Pharmacology. 146:95-103
Offspring of Sprague–Dawley derived dams were exposed to either 2,4,2′,4′-tetrachlorobiphenyl (TCB) (1, 10, or 20 mg/(kg·day)) or 3,4,3′,4′-TCB (0.1 or 1 mg/(kg·day)) from gestational Day 6 through weaning by providing the dams with cooki
Publikováno v:
Toxicology and Applied Pharmacology. 45:797-807
Fifteen male rats were treated with methadone-HCl (Meth) at 10 mg/kg sc per day for 12 days and an equal number received injections of sterile distilled water. Each male was caged with four untreated females each night. A necropsy was performed on ma
Autor:
R.G. York, Jeanne M. Manson
Publikováno v:
Toxicology and Applied Pharmacology. 72:417-426
This study was conducted to determine if the Ah genotype in mice could influence the incidence of neonatal mortality following maternal exposure to 3-methylcholanthrene (3-MC). Male F1 hybrids ( Ah b Ah d ) produced from a cross of C57BL 6J and DBA 2
Publikováno v:
Toxicology and Applied Pharmacology. 13:420-430
Three fungicides, captan, folpet, and Difolatan, were found to be nonteratogenic in two strains of rabbits that were particularly sensitive to the embryotoxic effects of thalidomide. Two metabolic products, phthalimide and tetrahydrophthalimide were
Autor:
Paul E. Palm, Elsie P. Arnold, Charles J. Kensler, John C. Leyczek, Kenneth W. Teague, Peter C. Rachwall
Publikováno v:
Toxicology and applied pharmacology. 44(1)
Dilutions of fresh-brewed coffee, at 12.5, 25, and 50% resulting in caffeine intakes of approximately 9, 19, and 38 mg/kg/day, respectively, were consumed by female rats as their sole beverage for 5 weeks prior to mating, throughout gestation and, in
Publikováno v:
Toxicology and applied pharmacology. 21(4)
The potoxicities of clindamycin hydrochloride and clindamycin palmitate have been extensively studied in mice, rats and dogs. For the hydrochloride, the ip mouse and po rat LD50 values were 361 and 2618 mg/kg, respectively. The values for the palmita