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Publikováno v:
Toxicology and applied pharmacology. 345
Pulmonary fibrosis is a chronic progressive disease with unknown etiology and has poor prognosis. Polyhexamethyleneguanidine phosphate (PHMG-P) causes acute interstitial pneumonia and pulmonary fibrosis in humans when it exposed to the lung. In a pre
Autor:
Jie Ping, Dan Xu, Lian Liu, Zheng He, Lu Ma, Hui Wang, Zixin Deng, Hao Kou, Hanwen Luo, Liaobin Chen, Lang Shen
Publikováno v:
Toxicology and Applied Pharmacology. 274:383-392
Our previous studies have demonstrated that prenatal caffeine ingestion induces an increased susceptibility to metabolic syndrome with alterations of glucose and lipid metabolic phenotypes in adult first generation (F1) of intrauterine growth retarda
Autor:
Nadia M. Hamdy, Ebtehal El-Demerdash
Publikováno v:
Toxicology and Applied Pharmacology. 261:292-299
Portal hypertension is a common complication of chronic liver diseases associated with liver fibrosis and cirrhosis. At present, beta-blockers such as carvedilol remain the medical treatment of choice for protection against variceal bleeding and othe
Publikováno v:
Toxicology and Applied Pharmacology. 226:84-93
Streptozotocin (STZ) is a naturally occurring compound isolated from Streptomyces achromogens. It is used extensively for inducing diabetes in experimental animals. Diabetes mellitus is known to have proven adverse effects on male sexual organs and t
Autor:
Akira Yasutake, Akinori Shimada, Tadashi Okawara, Yorishige Imamura, Hideaki Shimada, Morio Kiyozumi, Makiko Takahashi
Publikováno v:
Toxicology and Applied Pharmacology. 202(1):59-67
The Long–Evans Cinnamon (LEC) rat is a mutant strain that accumulates excessive tissue copper (Cu) and models the clinical symptoms and biological features of Wilson's disease in humans. We compared the effects of three metal chelating agents, N -b
Publikováno v:
Toxicology and Applied Pharmacology. 200:54-63
Triadimefon (TDF) is a triazole fungicide that acts as an indirect dopamine (DA) agonist by binding to the dopamine transporter (DAT) and increasing levels of synaptic DA. Studies in this laboratory have found that repeated dosing with TDF in adult m
Publikováno v:
Toxicology and Applied Pharmacology. 189:139-150
Disulfiram, a dithiocarbamate drug used in alcohol aversion therapy, produces a peripheral neuropathy characterized in rats as segmental demyelination accompanied by generation of S-(diethylaminocarbonyl)cysteine (DETC-Cys) adducts. N,N-Diethyldithio
Publikováno v:
Toxicology and Applied Pharmacology. 187:38-49
Occupational exposure to low-molecular-weight (LMW) allergens such as acid anhydrides can result in occupational asthma, an allergic disease characterized by episodic airway obstruction, airways inflammation, and non specific airways hyperresponsiven
Autor:
Ingerid Arbo, Petter Aadahl, Odd G. Nilsen, Arne K. Sandvik, Turid Nilsen, Helge L. Waldum, Øyvind Ellingsen, Jan Pål Loennechen
Publikováno v:
Toxicology and Applied Pharmacology. 178:8-14
The aims of the present study were to determine the effects of endothelin ET(A) receptor antagonism on carbon monoxide (CO)-induced cardiac hypertrophy and endothelin-1 (ET-1) expression and to compare myocardial effects of chronic nicotine with CO e
Publikováno v:
Toxicology and Applied Pharmacology. 134:53-62
Chlorpyrifos, one of the most widely used pesticides, exhibits greater toxicity during development than in adulthood. We administered chlorpyrifos to neonatal rats in apparently subtoxic doses that caused no mortality and little or no weight deficits