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Autor:
Akira Yasutake, Akinori Shimada, Tadashi Okawara, Yorishige Imamura, Hideaki Shimada, Morio Kiyozumi, Makiko Takahashi
Publikováno v:
Toxicology and Applied Pharmacology. 202(1):59-67
The Long–Evans Cinnamon (LEC) rat is a mutant strain that accumulates excessive tissue copper (Cu) and models the clinical symptoms and biological features of Wilson's disease in humans. We compared the effects of three metal chelating agents, N -b
Autor:
William T. Allaben, Nalini Agrawal, John E. Seng, Tatiana I. Leakey, Shijun Xia, Elizabeth T.M. Horsley, Erin M. Scherer, Julian E.A. Leakey
Publikováno v:
Toxicology and Applied Pharmacology. 193:281-292
Chloral hydrate is widely used as a sedative in pediatric medicine and is a by-product of water chlorination and a metabolic intermediate in the biotransformation of trichloroethylene. Chloral hydrate and its major metabolite, trichloroacetic acid, i
Pharmacodynamic Responses of F344 Rats to the Mouse Hepatocarcinogen Oxazepam in a 90-Day Feed Study
Autor:
Michael L. Cunningham, John R. Bucher
Publikováno v:
Toxicology and Applied Pharmacology. 149:41-48
Oxazepam (Serax) is a widely used benzodiazepine anxiolytic agent and a metabolite of other benzodiazepines such as Valium and Librium. Chronic feeding studies indicated that oxazepam is an hepatocarcinogen in B6C3F1 mice but did not increase hepatic
Autor:
Harri Vainio, Eivor Elovaara, Vesa Riihimäki, Tamie Nakajima, M. Klockars, Toshifumi Aoyama, Harry V. Gelboin, T. Okino
Publikováno v:
Toxicology and Applied Pharmacology. 133:215-222
The contribution of cytochrome P450 isozymes CYP2E1 and CYP2B1/2 to chloroform-induced hepatotoxicity taken at 18 hr after the treatment was investigated in rats treated with n-hexane as an inducer of CYP2E1, 2-hexanone as an inducer of CYP2E1 and CY
Publikováno v:
Toxicology and applied pharmacology. 247(1)
Acetaminophen (APAP) is the leading cause of drug induced liver failure in the United States. Previous studies in our laboratory have shown that S-adenosyl methionine (SAMe) is protective for APAP hepatic toxicity. SAMe is critical for glutathione sy
Autor:
Geert F. Houben, Willem Seinen, Bert W. Lam, Marga H.M. Kuijpers, Henk Van Loveren, AndréH. Penninks, Henk van den Berg
Publikováno v:
Toxicology and Applied Pharmacology. 113:43-54
Administration of ammonia caramel color (AC) to rats may decrease blood lymphocyte counts, specifically in rats fed a diet low in vitamin B6. This effect is associated with 2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole (THI). To characterize and
Autor:
Michael Schwarz, Albrecht Buchmann, Stephen K. Durham, Susanne Ziegler, Larry W. Robertson, Armin Wolf
Publikováno v:
Toxicology and Applied Pharmacology. 111:454-468
In the present study the promoting activity of various PCB and PBB isomers and congeners in rat liver has been studied and compared with a variety of primary xenobiotic-mediated enzymatic changes in this target organ. Female Wistar rats were given di
Publikováno v:
Toxicology and Applied Pharmacology. 111:99-106
Induction of hepatic UDP-glucuronyltransferase(s) (hUDP-GT(s] activity toward thyroid hormones and the relationship between the activity and the serum thyroid hormones or the thyroid stimulating hormone (TSH) level were examined in male Sprague-Dawle
Autor:
William T. Padgett, Guy R. Lambert, Sheau-Fung Thai, Pei-Jen Chen, Stephen Nesnow, Susan D. Hester, Tanya Moore, Witold Winnik
Publikováno v:
Toxicology and applied pharmacology. 234(2)
Conazoles are fungicides used in agriculture and as pharmaceuticals. In a previous toxicogenomic study of triazole-containing conazoles we found gene expression changes consistent with the alteration of the metabolism of all trans-retinoic acid (atRA
Publikováno v:
Toxicology and Applied Pharmacology. 102:34-49
Although carbon tetrachloride (CCl 4 ) is of concern as a drinking water contaminant, it has been necessary in most oral toxicity studies to give CCl 4 in an oil vehicle due to its limited water solbility. The primary objective of our study was to as