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Publikováno v:
Toxicology and applied pharmacology. 345
Pulmonary fibrosis is a chronic progressive disease with unknown etiology and has poor prognosis. Polyhexamethyleneguanidine phosphate (PHMG-P) causes acute interstitial pneumonia and pulmonary fibrosis in humans when it exposed to the lung. In a pre
Autor:
Akira Yasutake, Akinori Shimada, Tadashi Okawara, Yorishige Imamura, Hideaki Shimada, Morio Kiyozumi, Makiko Takahashi
Publikováno v:
Toxicology and Applied Pharmacology. 202(1):59-67
The Long–Evans Cinnamon (LEC) rat is a mutant strain that accumulates excessive tissue copper (Cu) and models the clinical symptoms and biological features of Wilson's disease in humans. We compared the effects of three metal chelating agents, N -b
Publikováno v:
Toxicology and Applied Pharmacology. 187:38-49
Occupational exposure to low-molecular-weight (LMW) allergens such as acid anhydrides can result in occupational asthma, an allergic disease characterized by episodic airway obstruction, airways inflammation, and non specific airways hyperresponsiven
Publikováno v:
Toxicology and Applied Pharmacology. 94:254-265
A study was conducted to determine the mode of action for phenobarbital promotion of thyroid follicular cell neoplasia in rats using an initiation-promotion model established by Hiasa et al. (Y. Hiasa, Y. Kitahori, M. Ohshima, T. Fujita, T. Yuasa, N.
Autor:
James E. Fitzgerald, F. A. de la Iglesia, John A. Anderson, J. R. Watkins, U. Jayasekara, Sang-Nam Kim
Publikováno v:
Toxicology and Applied Pharmacology. 77:369-373
The cardiac functional and tissue changes produced by the antineoplastic agent, amsacrine, were evaluated in CD male rats. Amsacrine was administered intraperitoneally to groups of 12 male rats in single weekly doses of 12, 6, and 3 mg/m2 for 13 week
Publikováno v:
Toxicology and Applied Pharmacology. 45:797-807
Fifteen male rats were treated with methadone-HCl (Meth) at 10 mg/kg sc per day for 12 days and an equal number received injections of sterile distilled water. Each male was caged with four untreated females each night. A necropsy was performed on ma
Publikováno v:
Toxicology and Applied Pharmacology. 77:108-115
Aztreonam (SQ 26,776) was given subcutaneously to three groups of neonatal rats at daily doses of 150, 600, and 2400 mg/kg from postnatal Days 10 through 16. Two similar groups given 400 mg of streptomycin kg −1 day −1 or 12 ml of 0.9% sodium chl
Publikováno v:
Toxicology and Applied Pharmacology. 49:425-430
Fischer 344 rats of both sexes were fed diets containing or lacking tolazamide, tolbutamide, chlorpropamide, acetohexamide, or phenformin for 78 or 103 weeks. A complete necropsy was performed on each rat and several tissues were examined histologica
Publikováno v:
Toxicology and Applied Pharmacology. 35:515-521
Fifty male inbred Syrian hamsters, aged 60–90 days, received a diet reduced in caloric content by 20% methylcellulose, or a diet containing 20% snuff (powdered tobacco), or 50 (5 mg) gavages of 20-methylcholanthrene (MC) in addition to chow, or 50
Publikováno v:
Toxicology and Applied Pharmacology. 19:93-102
These studies investigated the toxicology of combinations of glycopyrrolate (1-methyl-3-pyrrolidyl α-phenylcyclopentaneglycolate methobromide; Robinul®) with phenobarbital, meprobamate, tybamate, mephenoxalone, and with butaperazine. They involved