Zobrazeno 1 - 10
of 582
pro vyhledávání: ''
Publikováno v:
Toxicology and applied pharmacology. 427
Mitochondrial injury contributes to severe drug-induced liver injury. Particularly, mitochondrial permeability transition (MPT) is thought to be relevant to cytolytic hepatitis. However, the mechanism of drug-induced MPT is unclear and prediction of
Autor:
Sandra Maria Miraglia, Vanessa Vendramini, G.S. Souza, J.C. Souza, Camila Cicconi Paccola, I.M.M. Freitas, L.L. Martins
Publikováno v:
Toxicology and applied pharmacology. 426
Gonadal development begins in the intrauterine phase and females from most species are born with an established oocyte reserve. Exposure to drugs during gestation can compromise the offspring health, also affecting the gametes quality. Nicotine, the
Publikováno v:
Toxicology and applied pharmacology. 423
The expression of transporters on the apical and basal membranes of renal proximal tubular cells are down- or upregulated to various extents under cisplatin (CDDP)-induced acute kidney injury (AKI). However, little is known about the changes in trans
Autor:
Damien Richard, Alain Eschalier, Raalib Amode, Julie Vein, Bruno Pereira, Yohann Wittrant, Aurore Collin, Christelle Guillet, David Balayssac
Publikováno v:
Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2021, 425, pp.115600. ⟨10.1016/j.taap.2021.115600⟩
Toxicology and Applied Pharmacology, 2021, 425, pp.115600. ⟨10.1016/j.taap.2021.115600⟩
Toxicology and Applied Pharmacology, Elsevier, 2021, 425, pp.115600. ⟨10.1016/j.taap.2021.115600⟩
Toxicology and Applied Pharmacology, 2021, 425, pp.115600. ⟨10.1016/j.taap.2021.115600⟩
International audience; Among postmenopausal women with estrogen receptor-positive breast cancer, more than 80% receive hormone therapy including aromatase inhibitors (AIs). Half of them develop chronic arthralgia - characterized by symmetric articul
Publikováno v:
Toxicology and applied pharmacology. 409
The antimalarial drug artesunate (Art) has proven its beneficial effects against ischemia/reperfusion (I/R) injury in diverse organs, but its potential role against hepatic I/R is still obscure. This study, hence, examined whether treatment with Art
Publikováno v:
Toxicology and applied pharmacology. 399
The cardiotoxicity caused by doxorubicin and extravasation injury caused by anthracyclines is reduced by the clinically approved bisdioxopiperazine drug dexrazoxane. Dexrazoxane is a rings-closed analog of EDTA and is hydrolyzed in vivo to a form tha
Autor:
Adi Neufeld-Cohen, Shlomi Baranes, Ariel Gore, Shira Chapman, Ettie Grauer, Shlomi Lazar, Inbal Egoz, Rellie Gez
Publikováno v:
Toxicology and applied pharmacology. 395
Background Sarin is an irreversible organophosphate cholinesterase inhibitor. Following toxic signs, an extensive long-term brain damage is often reported. Thus, we evaluated the efficacy of a novel anticonvulsant drug retigabine, a modulator of neur
Autor:
Yu-Ming Kang, Yan Du, Meng-Lu Xu, Jie Qi, Jian-Qiang Zhao, Hong-Bao Li, Guo-Qing Zhu, Shao-Wen Zhou, Xiao-Jing Yu, Ying Li, Qing Yang, Meng-Meng Du, Qing Su, Wen-Jie Xia
Publikováno v:
Toxicology and applied pharmacology. 394
The hypothalamic paraventricular nucleus (PVN) plays crucial roles in central cardiovascular regulation. Increasing evidence in humans and rodents shows that vitamin D intake is important for achieving optimal cardiovascular function. The purpose of
Autor:
Wasana Pratchayasakul, Anusorn Lungaphin, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Laongdao Thongnak, Anchalee Pongchaidecha, Pattarapong Satjaritanun, Kenneth Chattipakorn, Siriporn C. Chattipakorn
Publikováno v:
Toxicology and Applied Pharmacology. 342:79-85
Although insulin and atorvastatin have been shown to exert glycemic control and could improve brain function, the effects of atorvastatin or insulin as well as the combination of atorvastatin plus insulin on brain pathology in diabetes mellitus type
Publikováno v:
Toxicology and Applied Pharmacology. 340:39-48
As a part of the serotoninergic dysfunction implicated in neurobiology of depression, evidence has focused on serotonin (5-HT) receptors downstream signaling intermediates including glycogen synthase kinase-3β (GSK-3β), cAMP response element bindin