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Autor:
S Arvinda, Dilip M. Mondhe, Jyotsna Suri, Gurdarshan Singh, Surinder Koul, Surjeet Singh, Ram A. Vishwakarma, Amarinder Singh
Publikováno v:
Toxicology and Applied Pharmacology. 318:8-15
The limiting factor for the use of Cisplatin in the treatment of different type of cancers is its toxicity and more specifically urogenital toxicity. Oxidative stress is a well-known phenomenon associated with Cisplatin toxicity. However, in Cisplati
Autor:
Adrienne M. Bushau, Anna L. Lang, Amanda N. Douglas, Craig J. McClain, Lisanne C. Anders, Matthew C. Cave, Juliane I. Beier, Brenna R. Kaelin, Heegook Yeo, Gavin E. Arteel
Publikováno v:
Toxicology and Applied Pharmacology. 311:34-41
Background Vinyl chloride (VC) causes toxicant-associated steatohepatitis at high exposure levels. Recent work by this group suggests that underlying liver disease may predispose the liver to VC hepatotoxicity at lower exposure levels. The most commo
Autor:
Viviana A. Catania, María Laura Ruiz, María Teresa Ronco, Nadia Ciriaci, Juan Pablo Rigalli, Virginia Gabriela Perdomo, José E. Manautou, Daniel E. Francés, Carolina Inés Ghanem, Amy M. Bataille
Publikováno v:
Toxicology and Applied Pharmacology. 304:90-98
Oxidative stress is a frequent cause underlying drug-induced hepatotoxicity. Benznidazole (BZL) is the only antitripanocide agent available for treatment of Chagas disease in endemic areas. Its use is associated with side effects, including increases
Autor:
Xiaochun Wan, Kang Sun, Jinsong Zhang, Ethan Will Taylor, Shengrong Li, Yijun Wang, Dongxu Wang, Hongjuan Lu
Publikováno v:
Toxicology and Applied Pharmacology. 265:342-350
Thioredoxin reductase (TrxR) is a target for cancer therapy and the anticancer mechanism of cisplatin involves TrxR inhibition. We hypothesize that the anticancer drug nedaplatin (NDP), an analogue of cisplatin and a second-generation platinum comple
Publikováno v:
Toxicology and Applied Pharmacology. 264:413-422
Valproic acid (VPA) undergoes cytochrome P450-mediated desaturation to form 4-ene-VPA, which subsequently yields (E)-2,4-diene-VPA by β-oxidation. Another biotransformation pathway involves β-oxidation of VPA to form (E)-2-ene-VPA, which also gener
Autor:
Mardi M. Algandaby, Hanaa M. Abdel-Rahman, Ebtehal El-Demerdash, Ashraf B. Abdel-Naim, Noha M. Saeed, Fahad A. Al-Abbasi
Publikováno v:
Toxicology and Applied Pharmacology. 264:84-93
Methyl palmitate (MP) and ethyl palmitate (EP) are naturally occurring fatty acid esters reported as inflammatory cell inhibitors. In the current study, the potential anti-inflammatory activity of MP and EP was evaluated in different experimental rat
Publikováno v:
Toxicology and applied pharmacology. 298
P-glycoprotein (P-gp) is a member of the ATP-binding cassette transporter family. It actively transports a wide variety of compounds out of cells to protect humans from xenobiotics. Thus, determining whether chemicals are substrates and/or inhibitors
Autor:
Rogério Faustino Ribeiro Júnior, Bruna F Azevedo, María J. Alonso, Dalton Valentim Vassallo, Alessandra Simão Padilha, Jonaina Fiorim, Ivanita Stefanon, Maylla Ronacher Simões, Mercedes Salaices
Publikováno v:
Toxicology and Applied Pharmacology. 262(1):22-31
Seven day exposure to a low concentration of lead acetate increases nitric oxide bioavailability suggesting a putative role of K+ channels affecting vascular reactivity. This could be an adaptive mechanism at the initial stages of toxicity from lead
Publikováno v:
Toxicology and Applied Pharmacology. 257:59-66
The efficacy of arsenic trioxide (ATO) against acute promyelocytic leukemia (APL) and relapsed APL has been well documented. ATO may cause DNA damage by generating reactive oxygen intermediates. Suberoylanilide hydroxamic acid (SAHA), a histone deace
Publikováno v:
Toxicology and Applied Pharmacology. 241:14-22
Primaquine, an 8-aminoquinoline, is the drug of choice for radical cure of relapsing malaria. Use of primaquine is limited due to its hemotoxicity, particularly in populations with glucose-6-phosphate dehydrogenase deficiency [G6PD(-)]. Biotransforma