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Publikováno v:
Toxicology and Applied Pharmacology. 164:176-183
Acrolein, an unsaturated aliphatic aldehyde, is a potent respiratory irritant. We have previously observed that acrolein administered ex vivo to isolated airways alters subsequent airway responsiveness to muscarinic agonists in terms of both mechanic
Publikováno v:
Toxicology and applied pharmacology. 206(1)
Nicotine and chlorpyrifos are developmental neurotoxicants that, despite their differences in structure and mechanism of action, share many aspects for damage to the developing brain. Both are thought to generate oxidative radicals; in the current st
Publikováno v:
Toxicology and Applied Pharmacology. 27:271-282
Intravenous administration of 2 new triazine antimalarials, BRL 50216 (clociguanil) and BRL 6231, to anesthetized dogs and cats revealed that both these agents had sympathomimetic actions. However, these actions differed for the 2 compounds for where
Publikováno v:
Toxicology and Applied Pharmacology. 36:595-601
The effect of methanol and other alcohols, sodium formate, and known vasoactive agents on isolated canine basilar artery was examined. Clinical concentrations of either methanol or sodium formate (approx 200 and 60 mg/100 ml, respectively) produced s
Publikováno v:
Toxicology and applied pharmacology. 43(3)
The effect of tin on gastric acid secretion was examined in phylorus-ligated rats. A single ip administration of stannous tin (1 mg/100 g) markedly decreased total acidity in gastric contents. A single sc injection of histamine (2 mg/100 g), tetragas
Autor:
Neil R. Ackerman
Publikováno v:
Toxicology and applied pharmacology. 41(2)
Δ 9 -THC has bronchodilator and antiasthmatic activity in humans. The current studies were undertaken in the guinea pig to determine if it were either a bronchial smooth muscle relaxant or an antagonist of one or more of the allergic mediators. Trac
Publikováno v:
Toxicology and applied pharmacology. 72(3)
In spite of worldwide research efforts in the search for the treatment of organophosphate poisoning, the substances with practical antidotal capabilities remain to be discovered. This problem has generally been approached by attempting to reactivate