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Autor:
Zhao Peng, Yuxiao Liao, Ping Yao, Andreas K. Nussler, Liegang Liu, Shuang Liu, Wei Yang, Zhilei Shan, Hong Yan, Liangkai Chen
Publikováno v:
Toxicology and Applied Pharmacology. 374:20-31
Deoxynivalenol (DON) is one of the most common mycotoxins which contaminate cereals and their by-products worldwide. Previous studies have stated toxic effects of DON on liver. Heme oxygenase-1 (HO-1) plays a potential role in protecting liver and ma
Autor:
Yajun Wang, Rui Liu, Yingnan Zeng, Di Wei, Hongli An, Yongjing Zhang, Yajing Hou, Tao Zhang, Shiling Hu, Chaomei Li, Delu Che
Publikováno v:
Toxicology and Applied Pharmacology. 366:46-53
The classical mast cells degranulation pathway is mediated by FcεRI aggregation and varies in strength among subjects. Dehydroandrographolide (DA) is one of principal components of Andrographis paniculata (Burm.f.) Nees (family: Acanthaceae) and con
Autor:
Xiao-Jing Yu, Hong-Bao Li, Wen-Jie Xia, Yu-Ming Kang, Qing Su, Ying Li, Juan Bai, Meng-Meng Du, Xiao-Min Wang, Chang-Xing Li, Zhi-Ming Dai, Meng-Lu Xu, Yuan-Yuan Dong
Publikováno v:
Toxicology and Applied Pharmacology. 429:115701
Gut dysbiosis and dysregulation of gut–brain communication have been identified in hypertensive patients and animal models. Previous studies have shown that probiotic or prebiotic treatments exert positive effects on the pathophysiology of hyperten
Publikováno v:
Toxicology and Applied Pharmacology. 327:30-38
Quercetin is a natural product that is sold as a supplement in health food stores. While there are reported benefits for this flavonoid as a dietary supplement due to antioxidant properties, the full scope of its biological interactions has not been
Autor:
Beatriz Abdallah Chaibub, Suzana C. Santos, Lee Chen-Chen, Dwight Assis Chaves, Cristiene Costa Carneiro, Ruy de Souza Lino, Paulo Roberto de Melo Reis, Maria Teresa Freitas Bara, Luana Santos Silva, Daniela de Melo e Silva, Antonio Jorge Ribeiro da Silva
Publikováno v:
Toxicology and Applied Pharmacology. 310:1-8
Punicalagin is the major ellagitannin constituent from leaves of Lafoensia pacari, a Brazilian medicinal plant widely used for the treatment of peptic ulcer and wound healing. Genotoxic, cytotoxic, antigenotoxic, and anticytotoxic effects of punicala
Autor:
Jeremiah N. Shields, Monazza Shahab, Samson Jamesdaniel, Rita Rosati, Tracie R. Baker, Danielle N. Meyer, Emily J. Crofts
Publikováno v:
Toxicol Appl Pharmacol
Generation of reactive oxygen species, a critical factor in cisplatin-induced ototoxicity, leads to the formation of peroxynitrite, which in turn results in the nitration of susceptible proteins. Previous studies indicated that LMO4, a transcriptiona
Publikováno v:
Toxicology and Applied Pharmacology. 402:115115
Physalin A (PA), a withanolide, was isolated from Physalis angulata L. In this study, it is shown that PA can inhibit the production of inflammatory cytokines such as PGE2, NO, IL-1β, IL-6, and TNF-α in LPS-induced RAW 264.7 cells. Furthermore, the
Autor:
Tharnath Nanthirudjanar, Tatsuya Sugawara, Nahoko Kitamura, Jun Ogawa, Shigenobu Kishino, Hidehiro Furumoto, Si-Bum Park, Toshiaki Kume, Yasuhiko Izumi, Takashi Hirata
Publikováno v:
Toxicology and Applied Pharmacology. 296:1-9
Oxidative stress is a well-known cause of multiple diseases. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway plays a central role in cellular antioxidative responses. In this study, we investigated th
Autor:
Cristina C. Jacob, Katelin S. Matazel, Matthew Bryant, Ying Deng-Bryant, Jennifer E. Naylor, Susan Chemerynski, Kia J. Jackson, Lucie Loukotková, Jeffrey W. Fisher, Chad J. Reissig, Amy K. Goodwin, Xiaoxia Yang, Gonçalo Gamboa da Costa
Publikováno v:
Toxicology and Applied Pharmacology. 386:114826
The widespread use and high abuse liability of tobacco products has received considerable public health attention, in particular for youth, who are vulnerable to nicotine addiction. In this study, adult and adolescent squirrel monkeys were used to ev
Autor:
Yujie Li, Yan Guo, Ya-Jie Wang, Xiaogang Weng, Xiaoxin Zhu, Zdenìk Zídek, Xi Chen, Dong Zhang, Lan Yang, Xu-Cen Liu, Qing Yang, Xiao-Xi Kan, Qi Li, Eva Kmoníèková, Ying Chen
Publikováno v:
Toxicology and Applied Pharmacology. 286:151-158
The aim of our experiments was to investigate the anti-inflammatory properties of casticin and chrysosplenol D, two flavonoids present in Artemisia annua L.Topical inflammation was induced in ICR mice using croton oil. Mice were then treated with cas