Zobrazeno 1 - 10
of 771
pro vyhledávání: ''
Publikováno v:
Toxicology. 461
The current publication describes most recent so far unpublished (key) guideline and GLP compliant reproductive and developmental toxicity studies of lithium carbonate in rats, including their interpretation and conclusions in terms of human hazard a
Autor:
Anni Fan, Mengmeng Wang, Nanxi Bi, Ruiqing Zhou, Xiaozhen Gu, Hui-Li Wang, Quan-Cai Sun, Danyang Li
Publikováno v:
Toxicology. 465
Bisphenol-A (BPA), an environmental endocrine disruptor, is toxic to the central nervous system. Although recent studies have shown BPA-induced neurotoxicity, it is far from clear what precisely epigenetic mechanisms are involved in BPA-induced cogni
Autor:
Ethel Eljarrat, Guillaume Antoine, Flavien Denis, Jean-Philippe Sabaté, Anne-Marie Saillenfait, Alain Robert
Publikováno v:
Toxicology. 410:116-124
The present study investigated the effects of maternal exposure to the widely used pyrethroid insecticides, permethrin and esfenvalerate, on fetal testicular steroidogenesis. Pregnant Sprague-Dawley rats were administered permethrin at doses of 1, 10
Publikováno v:
Toxicology. 453
Cisplatin-induced ototoxicity is one of the important reasons that limit the drug's clinical application, and its mechanism has not been fully elucidated so far. The aim of this study was to explore the attenuate effect of tauroursodeoxycholic acid (
Publikováno v:
Toxicology. 457
We have addressed in the current study the potential of L-carnitine (LC) to extenuate the reproductive toxic insults of carbendazim (CBZ) in male rats, and the molecular mechanisms whereby carnitine would modify the spermatogenic and steroidogenic de
Publikováno v:
Toxicology. 449
As a synthetic glucocorticoid, dexamethasone has been widely used in the clinical treatment of premature birth and related pregnant diseases, but its clinical use is still controversial due to developmental toxicity. This study aimed to confirm the p
Autor:
Hope Chinaza Ekuma, Timothy Joe Akpan, Chukwuemeka R. Nwokocha, Catherine Barong Kekung-Asu, Victor Udo Nna, Victoria Victor Fubara, Eme Efiom Osim, Mahaneem Mohamed, Godwin Adakole Ujah, Joseph Bagi Suleiman
Publikováno v:
Toxicology. 441
Cisplatin (Cis) is an effective chemotherapeutic intervention against many cancer types. However, the oxidative stress-related toxicities associated with cancer cell resistance-induced dose scaling has limited its long-term use. In the present study,
Publikováno v:
Toxicology. 441
Maternal nicotine exposure during pregnancy and lactation (NIC) is associated with dysfunction of white adipose tissue (WAT). We focused on the NIC-induced WAT angiogenesis and explored its sex and age differences. Pregnant rats were randomly assigne
Autor:
Yanqing Song, Wenrui Zhang, Huan Gao, Xiaoyu Qu, Lina Tao, Jinghui Zhai, Yueming Zhang, Xiangfeng Wang
Publikováno v:
Toxicology. 440
Renal toxicity is the primary factor that limits clinical use of cisplatin (CP). A previous study showed that omeprazole (OME) protected against CP-induced toxicity in human renal tubular HK-2 cells and rat kidneys. However, the protective mechanisms
Publikováno v:
Toxicology. :59-67
Imipenem/cilastatin is a broad-spectrum β-lactam antibiotic used to treat several bacterial infections. The present study was designed to validate the nephrotoxic effect of this drug in rats and to explore its potentional urolithiatic effect. Thirty