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Autor:
Takao Fukui, Tomomasa Ishikawa, Rie Murai, Kunihiko Asakura, Akihiro Ueda, Tatsuro Mutoh, Ken ichiro Murate, Seiko Hirota, Shinji Ito, Chika Hikichi, Madoko Kizawa
Publikováno v:
Toxicology. 331:112-118
Clioquinol is considered to be a causative agent of subacute myelo-optico neuropathy (SMON), although the pathogenesis of SMON is yet to be elucidated. We have previously shown that clioquinol inhibits nerve growth factor (NGF)-induced Trk autophosph
Autor:
Shuanglian Wang, Roy Nofech-Mozes, Fan Yi, Wei-Yang Lu, Allen L. Feng, Changhui Wang, Xupeng Yang, Ziwei Li, Yan Luo, Chuanyong Liu, Tao Li, Meng Yu
Publikováno v:
Toxicology. 326:44-52
Alcohol overindulgence is a risk factor of type 2 diabetes mellitus. However, the mechanisms by which alcohol overindulgence damages glucose metabolism remain unclear. Pancreatic islet β-cells are endowed with type-A γ-aminobutyric acid receptor (G
Autor:
Petra Kovarikova, Jaroslav Roh, Hana Jansová, Vit Sestak, Jan Bures, Galina Karabanovich, Tomas Simunek, Anna Jirkovská, Martin Sterba
Publikováno v:
Toxicology. 392
Novel dexrazoxane derivative JR-311 was prepared to investigate structure-activity relationships and mechanism(s) of protection against anthracycline cardiotoxicity. Its cardioprotective, antiproliferative, iron (Fe) chelation and inhibitory and/or d
Autor:
Shingo Takagi, Yu Yamaura, Tsuyoshi Yokoi, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, Naoyuki Tatsumi
Publikováno v:
Toxicology. 322:89-98
金沢大学ナノ生命科学研究所 / 金沢大学医薬保健研究域薬学系
MicroRNAs (miRNAs) in body fluids have received attention as potential biomarkers of organ damage because miRNAs that are highly or specifically expressed in a
MicroRNAs (miRNAs) in body fluids have received attention as potential biomarkers of organ damage because miRNAs that are highly or specifically expressed in a
Publikováno v:
Toxicology. 315:49-54
Tobacco smoking is a major risk factor for multiple human cancers including urinary bladder carcinoma. Tobacco smoke is a complex mixture containing chemicals that are known carcinogens in humans and/or animals. Aromatic amines a major class of DNA-r
Publikováno v:
Toxicology. 382
Imatinib mesylate is an effective treatment for chronic myelogenous leukemia and gastrointestinal stromal tumors. Although imatinib mesylate is highly tolerable, it has been implicated in severe congestive heart failure in mouse models and patients.
Publikováno v:
Toxicology. 370
A presynaptic protein SNAP-25 belonging to SNARE complex which is instrumental in intracellular vesicular trafficking and exocytosis, has been implicated in hyperactivity and cognitive abilities in some neuropsychiatric disorders. The unclear etiolog
Publikováno v:
Toxicology. 314:221-228
A treatment regimen consisting of HI-6, scopolamine, and physostigmine (termed the physostigmine regimen) has been based on the serendipitous discovery that it exerts powerful antidotal effects against high levels of soman poisoning if it is administ
Autor:
Daniel Escutia Calzada, Susana Enriqueta Frías González, Alberto Mendoza Herrera, Cynthia Ordaz Pichardo, Enrique Angeles Anguiano
Publikováno v:
Toxicology. 314:155-165
Cisplatin remains one of the most effective current chemotherapeutic agents; however, metal complexes synthesis has increased in order to produce new anti-neoplastic drugs with DNA binding and apoptotic activities in tumor cells and less toxicity for
Autor:
M. Alfonso, Lilian Rosana Ferreira Faro, Vania Moraes Ferreira, Brenda Viviane Ferreira Nunes, R. Durán
Publikováno v:
Toxicology. 311:154-161
The purpose of the present work was to assess the possible role of glutamatergic receptors and nitric oxide (NO) production on effects of glufosinate ammonium (GLA), an organophosphate pesticide structurally related to glutamate, on in vivo striatal