Zobrazeno 31 - 40
of 771
pro vyhledávání: ''
Autor:
C. Andrew Leach, W.Shane Bennett, Ronald B. Pringle, Joshua P. Bennett, Robert W. Wills, Howard W. Chambers, Janice E. Chambers, Edward C. Meek
Publikováno v:
Toxicology. 339:51-57
Novel substituted phenoxyalkyl pyridinium oximes, previously shown to reactivate brain cholinesterase in rats treated with high sublethal dosages of surrogates of sarin and VX, were tested for their ability to prevent mortality from lethal doses of t
Publikováno v:
Toxicology. 336:79-83
Novel nucleophiles, a series of substituted phenoxyalkyl pyridinium oximes, have been previously shown by our laboratories to enhance in vitro paraoxonase 1 (PON1)-mediated degradation of a sarin surrogate (nitrophenyl isopropyl methylphosphonate, NI
Publikováno v:
Toxicology. 441:152508
Doxorubicin (DOX) is one of the most effective and irreplaceable chemotherapeutic agents but its clinical use is limited due to its cardiotoxicity. Glycyrrhizin(GL) has been applied to liver disorders for long. However, little is known that if GL cou
Publikováno v:
Toxicology. 432:152378
Prenatal nicotine exposure (PNE) could induce an increased susceptibility to multiple chronic diseases in adult offspring, that mainly caused by intrauterine maternal glucocorticoid (GC) over-exposure. We investigated the changes and inheritability o
Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo
Autor:
Shugo Suzuki, Samuel M. Cohen, Karen L. Pennington, Taku Naiki, Hiroyuki Kato, Lora L. Arnold, Aya Naiki-Ito, Yoriko Yamashita, Satoru Takahashi
Publikováno v:
Toxicology. 429:152325
Tobacco smoking is a major risk factor for human cancers including urinary bladder carcinoma. In a previous study, nicotine enhanced rat urinary bladder carcinogenesis using a rat urinary bladder two-stage carcinogenesis model. In the present study,
Publikováno v:
Toxicology. 429:152326
Chlormequat chloride, a plant growth regulator, is widely applied in agriculture because it can promote sturdier growth of the crops. In this research, we found that rat embryo growth on GD11 was inhibited in vitro at 50 μg/ml but promoted in vivo a
Autor:
Yi-Ping Zhu, Sheng Zhao, Wen-Lan Sun, Bang-Min Han, Jun-Tao Jiang, Kristofer Wood, Xiao-Yu Bei, Cheng Shen, Deng Li
Publikováno v:
Toxicology.
Maternal exposure to di-n-butyl phthalate (DBP) induces hypospadias, but the underlying mechanisms remain elusive. Here we hypothesize that aberrant activation of autophagy and epithelial-mesenchymal transition (EMT) are the leading cause of DBP-rela
Autor:
Audrey Vardy, Lynsey R. Chatham, Larry G. Higgins, Barbara M. Elcombe, Corinne Haines, Brian G. Lake, Clifford R. Elcombe
Publikováno v:
Toxicology.
Phenobarbital (PB), a constitutive androstane receptor (CAR) activator, produces liver tumours in rodents by a mitogenic mode of action involving CAR activation. In this study, the hepatic effects of sodium phenobarbital (NaPB) were compared in male
Autor:
Tohru Yamakuni, Ichiro Kawahata
Publikováno v:
Toxicology. 394
Imidacloprid is a neonicotinoid insecticide acting as an agonist of nicotinic acetylcholine receptors (nAChRs) in the target insects. However, questions about the safety to mammals, including human have emerged. Overactivation of mammalian peripheral
Autor:
Paulo J. Oliveira, Cheryl Zehowski, Kendall B. Wallace, Andrew J Skildum, Kendra K. S. Nordgren, Cláudia M. Deus
Publikováno v:
Toxicology. 334:1-11
Doxorubicin (DOX) is currently used in cancer chemotherapy, however, its use often results in adverse effects highlighted by the development of cardiomyopathy and ultimately heart failure. Interestingly, DOX cardiotoxicity is decreased by resveratrol