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Autor:
Josiane de Lima Rosa, Patrícia Villela e Silva, André S. Pupo, Wilma De Grava Kempinas, Marina T. Guerra, Luiz Ricardo de Almeida Kiguti, Cibele dos Santos Borges, Ana Flávia M.G. Dias, Raquel Frenedoso da Silva
Publikováno v:
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2018-12-11T17:03:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-02-01 Betamethasone is the drug of choice for antenatal treatment, promoting fetal lung maturation, decreasing the incidence of respiratory distres
Autor:
Kevin L. Dreher, Diana Hall, Jenna D. Strickland, Timothy J. Shafer, William R. LeFew, James L. Crooks, Jayna N.R. Ortenzio
Publikováno v:
Toxicology. :1-8
Silver nanoparticles (AgNPs) are used in a wide range of consumer and medical products because of their antimicrobial and antifungal properties, and can translocate to the brain following exposure. Therefore, to screen AgNPs for potential impacts on
Autor:
Paulo J. Oliveira, Cheryl Zehowski, Kendall B. Wallace, Andrew J Skildum, Kendra K. S. Nordgren, Cláudia M. Deus
Publikováno v:
Toxicology. 334:1-11
Doxorubicin (DOX) is currently used in cancer chemotherapy, however, its use often results in adverse effects highlighted by the development of cardiomyopathy and ultimately heart failure. Interestingly, DOX cardiotoxicity is decreased by resveratrol
Autor:
Takao Fukui, Tomomasa Ishikawa, Rie Murai, Kunihiko Asakura, Akihiro Ueda, Tatsuro Mutoh, Ken ichiro Murate, Seiko Hirota, Shinji Ito, Chika Hikichi, Madoko Kizawa
Publikováno v:
Toxicology. 331:112-118
Clioquinol is considered to be a causative agent of subacute myelo-optico neuropathy (SMON), although the pathogenesis of SMON is yet to be elucidated. We have previously shown that clioquinol inhibits nerve growth factor (NGF)-induced Trk autophosph
Autor:
Shuanglian Wang, Roy Nofech-Mozes, Fan Yi, Wei-Yang Lu, Allen L. Feng, Changhui Wang, Xupeng Yang, Ziwei Li, Yan Luo, Chuanyong Liu, Tao Li, Meng Yu
Publikováno v:
Toxicology. 326:44-52
Alcohol overindulgence is a risk factor of type 2 diabetes mellitus. However, the mechanisms by which alcohol overindulgence damages glucose metabolism remain unclear. Pancreatic islet β-cells are endowed with type-A γ-aminobutyric acid receptor (G
Publikováno v:
Toxicology. 314:221-228
A treatment regimen consisting of HI-6, scopolamine, and physostigmine (termed the physostigmine regimen) has been based on the serendipitous discovery that it exerts powerful antidotal effects against high levels of soman poisoning if it is administ
Publikováno v:
Toxicology. 257:53-63
Increasing evidences in both experimental and clinical studies suggest that oxidative stress is involved in the pathogenesis of diabetic tissue damage. Pancreatic beta-cell death is the cause of decreased insulin production in diabetes. Streptozotoci
Autor:
Takeki Uehara, Taku Nagao, Toshinobu Shimizu, Yumiko Mizukawa, Mitsuhiro Hirode, Ko Omura, Tetsuro Urushidani, Toshikazu Miyagishima, Atsushi Ono, Naoki Kiyosawa
Publikováno v:
Toxicology. 250:15-26
For assessing carcinogenicity in animals, it is difficult and costly, an alternative strategy has been desired. We explored the possibility of applying a toxicogenomics approach by using comprehensive gene expression data in rat liver treated with va
Publikováno v:
Toxicology. 244:42-48
A synaptosomal model was used to evaluate in vivo effects of paraoxon on the uptake of [(3)H]GABA in rat cerebral cortex and hippocampus. Male Wistar rats were given a single intraperitoneal injection of one of three doses of paraoxon (0.1, 0.3, or 0
Publikováno v:
Toxicology. 243:155-163
This study was designed to investigate the effects of several pyrethroids on the extracellular level of glutamate and gamma-aminobutyric acid (GABA) in the hippocampus of rats measured using microdialysis following systemic (i.p.) administration. Pyr