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Publikováno v:
Toxicology. 461
The current publication describes most recent so far unpublished (key) guideline and GLP compliant reproductive and developmental toxicity studies of lithium carbonate in rats, including their interpretation and conclusions in terms of human hazard a
Publikováno v:
Toxicology. 449
As a synthetic glucocorticoid, dexamethasone has been widely used in the clinical treatment of premature birth and related pregnant diseases, but its clinical use is still controversial due to developmental toxicity. This study aimed to confirm the p
Publikováno v:
Toxicology. 441
Maternal nicotine exposure during pregnancy and lactation (NIC) is associated with dysfunction of white adipose tissue (WAT). We focused on the NIC-induced WAT angiogenesis and explored its sex and age differences. Pregnant rats were randomly assigne
Publikováno v:
Toxicology. :59-67
Imipenem/cilastatin is a broad-spectrum β-lactam antibiotic used to treat several bacterial infections. The present study was designed to validate the nephrotoxic effect of this drug in rats and to explore its potentional urolithiatic effect. Thirty
Publikováno v:
Toxicology. :57-64
Terbutaline and dexamethasone are used in the management of preterm labor, often for durations of treatment exceeding those recommended, and both have been implicated in increased risk of neurodevelopmental disorders. We used a variety of cell models
Autor:
Karla Nívea Sampaio, Daniela A. M. Guimarães, Julian F. R. Paton, Leonardo B.M. Resstel, Igor Simões Assunção Felippe, Alexandre F. Cunha, Vanessa Beijamini, Nilson C. Ferreira-Junior
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cunha, A F, Felippe, I S A, Ferreira-Junior, N C, Resstel, L B M, Guimarães, D A M, Beijamini, V, Paton, J F R & Sampaio, K N 2018, ' Neuroreflex control of cardiovascular function is impaired after acute poisoning with chlorpyrifos, an organophosphorus insecticide : Possible short and long term clinical implications ', Toxiocology, vol. 398-399, pp. 13-22 . https://doi.org/10.1016/j.tox.2018.02.005
Universidade de São Paulo (USP)
instacron:USP
Cunha, A F, Felippe, I S A, Ferreira-Junior, N C, Resstel, L B M, Guimarães, D A M, Beijamini, V, Paton, J F R & Sampaio, K N 2018, ' Neuroreflex control of cardiovascular function is impaired after acute poisoning with chlorpyrifos, an organophosphorus insecticide : Possible short and long term clinical implications ', Toxiocology, vol. 398-399, pp. 13-22 . https://doi.org/10.1016/j.tox.2018.02.005
Although it is well-established that severe poisoning by organophosphorus (OP) compounds strongly affects the cardiorespiratory system, the effects of sub-lethal exposure to these compounds on the neural control of cardiovascular function are poorly
Autor:
Lora L. Arnold, Satoshi Fuji, Karen L. Pennington, Shugo Suzuki, Aya Naiki-Ito, Samuel M. Cohen, Hiroyuki Kato, Yoriko Yamashita, Satoru Takahashi, Yuko Nagayasu
Publikováno v:
Toxicology. :31-40
Tobacco smoking is a major risk factor for human cancers including urinary bladder carcinoma. Cigarette smoke inhalation in mice and orally administered nicotine in rats and mice increased urothelial cell proliferation. Nicotine, a major component of
Autor:
Josiane de Lima Rosa, Patrícia Villela e Silva, André S. Pupo, Wilma De Grava Kempinas, Marina T. Guerra, Luiz Ricardo de Almeida Kiguti, Cibele dos Santos Borges, Ana Flávia M.G. Dias, Raquel Frenedoso da Silva
Publikováno v:
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2018-12-11T17:03:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-02-01 Betamethasone is the drug of choice for antenatal treatment, promoting fetal lung maturation, decreasing the incidence of respiratory distres
Autor:
Maibam Wanta Khuman, Subhashree Parida, Karam Pal Singh, Souvendra Nath Sarkar, Vattaparambil Sukumaran Susanth, Abdul Sadam, Manickam Kesavan, Sankaran Kutty Harikumar
Publikováno v:
Toxicology. 374:29-41
Arsenic exposure can cause several cardiovascular diseases, including hypertension, atherosclerosis and microvascular disease. Earlier, we reported that arsenic-mediated enhancement of angiotensin II (AngII) signaling can impair vascular physiology.
A scrutiny of circulating microRNA biomarkers for drug-induced tubular and glomerular injury in rats
Autor:
Tsuyoshi Yokoi, Tomáš Zárybnický, Shingo Oda, Takanao Omi, Yuji Shirai, Takumi Kagawa, Shinya Toyokuni
Publikováno v:
Toxicology. 415
Drug-induced acute kidney injury (AKI) is a frequent cause of adverse drug reaction. Serum creatinine (CRE) and blood urea nitrogen (BUN) are widely used as standard biomarkers for kidney injury; however, the sensitivity and specificity are considere