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Publikováno v:
Toxicology. 304:49-56
The industrial solvent trichloroethylene (TCE) has been reported to increase the excretion of formic acid in the urine of male Fischer 344 (F-344) rats following large oral doses. We have examined the dose-response relationship for formic aciduria in
Publikováno v:
Toxicology. 300:112-120
Methylmercury (MeHg) is one of the ubiquitous environmental toxicants, which can induce oxidative stress and an indirect excitotoxicity caused by altered glutamate (Glu) metabolism. However, little is known of the interaction between oxidative stress
Publikováno v:
Toxicology.
1-Methylpyrene, an alkylated polycyclic aromatic hydrocarbon and environmental carcinogen, is activated by side-chain hydroxylation to 1-hydroxymethylpyrene (1-HMP) and subsequent sulfo conjugation to the DNA-reactive 1-sulfooxymethylpyrene. In addit
Publikováno v:
Toxicology. 298:52-58
Thioacetamide is widely used in industry and is known to be one of the most potent hepatotoxicants in experimental animals. We investigated the involvement of flavin-containing monooxygenase (FMO)-dependent hepatic-neutrophil activation and the relea
Autor:
Maria de Lourdes Pires Bianchi, Alexandre Ferro Aissa, Regislaine Valéria Burim, Gustavo Rafael Mazzaron Barcelos, M.A. Alves da Cunha, Carla da Silva Machado, Michela Bianchi de Mello, Diego Luis Ribeiro, Lusânia Maria Greggi Antunes
Publikováno v:
Toxicology. 376
The lasiodiplodan (LS) is a β-(1→6)-d-glucan produced by the fungus Lasiodiplodia theobromae and some of the biological activities of LS were reported as hypoglycemic, anticoagulant, anti-proliferative and anticancer action; however, its effects o
Autor:
Robert Gelein, Jacob N. Finkelstein, Pamela Wade-Mercer, Alison Elder, Jingkun Jiang, Pratim Biswas, Günter Oberdörster, Nancy Corson, Xianglu Han
Publikováno v:
Toxicology. 287:99-104
Studies showed that certain cytotoxicity assays were not suitable for assessing nanoparticle (NP) toxicity. We evaluated a lactate dehydrogenase (LDH) assay for assessing copper (Cu-40, 40 nm), silver (Ag-35, 35 nm; Ag-40, 40 nm), and titanium dioxid
Autor:
Stephanie Padilla, Virginia C. Moser
Publikováno v:
Toxicology. 281:56-62
A variety of chemicals, such as organophosphate (OP) and carbamate pesticides, nerve agents, and industrial chemicals, inhibit acetylcholinesterase (AChE) leading to overstimulation of the cholinergic nervous system. The resultant neurotoxicity is si
Publikováno v:
Toxicology. 269:24-34
Acute exposure of acetaminophen (APAP), a widely used analgesic and antipyretic drug, causes severe renal damage and no specific agent has been reported so far that plays any beneficial role in this organ pathophysiology. In the present study, the pr
Autor:
Claire Racaud-Sultan, Maysaloun Merhi, Cécile Demur, F. Blas Y. Estrada, L. Gamet-Payrastre, Cécile Canlet, J. Bertrand
Publikováno v:
Toxicology. 267:80-90
Defining the impact on health of exposure to a low-dose pesticide mixture via food intake is a topical question since epidemiological studies suggest that this may increase the risk of pathologies and particularly haematopoietic malignancies. Here we
Autor:
Òscar Domènech, Hamdy A.A. Aly
Publikováno v:
Toxicology. 262:175-183
Polychlorinated biphenyls (PCBs) are widespread persistent environmental contaminants that display a complex spectrum of toxicological properties, including hepatotoxicity. Although Aroclor 1254 is ubiquitous in the environment, its potential cytotox