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Autor:
Anni Fan, Mengmeng Wang, Nanxi Bi, Ruiqing Zhou, Xiaozhen Gu, Hui-Li Wang, Quan-Cai Sun, Danyang Li
Publikováno v:
Toxicology. 465
Bisphenol-A (BPA), an environmental endocrine disruptor, is toxic to the central nervous system. Although recent studies have shown BPA-induced neurotoxicity, it is far from clear what precisely epigenetic mechanisms are involved in BPA-induced cogni
Autor:
C. Andrew Leach, W.Shane Bennett, Ronald B. Pringle, Joshua P. Bennett, Robert W. Wills, Howard W. Chambers, Janice E. Chambers, Edward C. Meek
Publikováno v:
Toxicology. 339:51-57
Novel substituted phenoxyalkyl pyridinium oximes, previously shown to reactivate brain cholinesterase in rats treated with high sublethal dosages of surrogates of sarin and VX, were tested for their ability to prevent mortality from lethal doses of t
Autor:
Piotr Listos, Izabela Gutowska, Sylwia Talarek, Joanna Listos, Agnieszka Kolasa, Marta Rybicka, Dariusz Chlubek, Sylwia Fidecka, Jolanta Orzelska, Irena Baranowska-Bosiacka
Publikováno v:
Toxicology. 310:73-83
The aim of this study was to investigate the behavioral and molecular effects of pre- and postnatal lead (Pb) exposure on the expression of morphine withdrawal and tolerance in adult rats. Rats were orally treated with 0.1% (1000 ppm) lead acetate fr
Autor:
Arpiné Ardzivian Elnar, Jaouad Bouayed, Rachid Soulimani, Frédéric Desor, Alexandra K. Kiemer, Britta Diesel, Cyril Feidt
Publikováno v:
Toxicology
Toxicology, Elsevier, 2012, 299 (1), pp.44-54. ⟨10.1016/j.tox.2012.05.004⟩
Toxicology, Elsevier, 2012, 299 (1), pp.44-54. ⟨10.1016/j.tox.2012.05.004⟩
In this study, the neurobehavioral toxicity of lactational exposure to a representative mixture of the six indicator non-dioxin-like-polychlorinated biphenyls (Sigma 6 NDL-PCBs 28, 52, 101, 138, 153 and 180) found in contaminated fish matrices were a
Publikováno v:
Toxicology. 265:34-40
Toluene, a widely used and commonly abused organic solvent, causes a variety of behavioral disturbances in both humans and animals. In this study, the effects of toluene on locomotor activity, motor coordination, and passive avoidance learning, along
Publikováno v:
Toxicology. 258:10-16
Ascorbate (AA), an antioxidant substance known as vitamin C, exists in the brain at a high concentration, although transfer into the brain after systemic administration of AA itself is limited. Intraperitoneal administration of dehydroascorbate (DHA)
Publikováno v:
Toxicology. 256:175-182
The present study was designed to explore the alternative mechanism (other than AChE inhibition) for chronic, low-level exposure to dichlorvos, an organophosphate, in vivo. Dichlorvos, at a dose of 1.0 and 6.0 mg/kg body weight (b.wt.) for 12 weeks,
Publikováno v:
Toxicology. 244:111-122
3-Nitropropionic acid (3-NP) is an irreversible inhibitor of the electron transport enzyme succinate dehydrogenase, a mitochondrial Complex II enzyme. Minocycline is a semi-synthetic second-generation tetracycline with neuroprotective activity and ha
Publikováno v:
Toxicology. 239:116-126
Neurosteroids (NS) are recognized as important modulators of functioning of the nervous system. Lindane, an organochlorine pesticide has been shown to adversely affect memory and induce oxidative stress on both acute and chronic exposure. The present
Autor:
David Balayssac, Bing Ling, Alain Eschalier, Nicolas Authier, Marie-Ange Coudoré-Civiale, François Coudoré
Publikováno v:
Toxicology. 234:176-184
In clinical use, a single infusion of oxaliplatin, widely used to treat metastatic colorectal cancer, induces specific sensory neurotoxicity signs triggered or aggravated by exposure to cold. To study the pathophysiology of these symptoms, we develop