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Publikováno v:
Toxicology. 244(2-3):249-256
The dopamine transporter has been shown to be the most relevant target site for the specificity of 1-methyl-4-phenylpyridinium ion (MPP+), a neurotoxin for dopaminergic neurons. In contrast, the mechanisms underlying the selective toxicity of mangane
Autor:
Rob C. A. Onderwater, Jan N. M. Commandeur, Wiro M. P. B. Menge, Astrid Sitters, Nico P. E. Vermeulen, E.J. Groot
Publikováno v:
Onderwater, R C A, Commandeur, J N M, Groot, E J, Sitters, A, Menge, W M P B & Vermeulen, N P E 1998, ' Cytotoxicity of a series of mono-and di-substituted thiourea in freshly isolated rat hepatocytes: a preliminary structure-toxicity relationship study. ', Toxicology, vol. 125, no. 2-3, pp. 117-129 . https://doi.org/10.1016/S0300-483X(97)00169-8
Toxicology, 125(2-3), 117-129. Elsevier Ireland Ltd
Toxicology, 125(2-3), 117-129. Elsevier Ireland Ltd
The cytotoxicity of a series of 12 mono- and 4 di-substituted thiourea containing compounds in freshly isolated rat hepatocytes was investigated. It was found that thiourea toxicity, as evidenced by an increase in LDH-leakage from the cells, was acco