Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Christopher Lau"'
Autor:
Robert M. Zucker, Christopher Lau, Curtis E. Grace, John M. Rogers, B.E. Grey, Joel Norwood, Robert G. Ellis-Hutchings, Christopher J. Gordon
Publikováno v:
Toxicological Sciences. 137:436-446
Adverse intrauterine environments have been associated with increased risk of later cardiovascular disease and hypertension. In an animal model using diverse developmental toxicants, we measured blood pressure (BP), renal nephron endowment, renal glu
Autor:
Matthew T. Martin, Keith A. Houck, Jamie C. DeWitt, R. Woodrow Setzer, Ann Pitruzzello, Christopher Lau, Mark J. Strynar, John F. Wambaugh, Jie Liu, Kaberi P. Das, Richard S. Judson, Nicole Kleinstreuer, David M. Reif, Nisha S. Sipes, Nina Ching Y. Wang
Publikováno v:
Toxicological Sciences. 136:308-327
In order to compare between in vivo toxicity studies, dosimetry is needed to translate study-specific dose regimens into dose metrics such as tissue concentration. These tissue concentrations may then be compared with in vitro bioactivity assays to p
Autor:
Hongzu Ren, J. Christopher Corton, Janice S. Lee, Jie Liu, Christopher Lau, Mitchell B. Rosen, Beena Vallanat, Michael P. Waalkes, Barbara D. Abbott
Publikováno v:
Toxicological Sciences. 103:46-56
A number of perfluorinated alkyl acids including perfluorooctanoic acid (PFOA) elicit effects similar to peroxisome proliferator chemicals (PPC) in mouse and rat liver. There is strong evidence that PPC cause many of their effects linked to liver can
Autor:
Christopher Lau, Kendall B. Wallace, John L. Butenhoff, Shu Ching Chang, Melvin E. Andersen, Geary W. Olsen, Jennifer Seed, David G. Farrar, Gerald L. Kennedy
Publikováno v:
Toxicological Sciences. 102:3-14
The perfluoroalkyl acid salts (both carboxylates and sulfonates, hereafter designated as PFAAs) and their derivatives are important chemicals that have numerous consumer and industrial applications. However, recent discoveries that some of these comp
Autor:
J. Christopher Corton, Carmen R. Wood, Richard J. Brennan, Wenyue Hu, Matthew T. Martin, Robert J. Kavlock, David J. Dix, Eser Ayanoglu, Christopher Lau, Hongzu Ren
Publikováno v:
Toxicological Sciences. 97:595-613
Toxicogenomic analysis of five environmental chemicals was performed to investigate the ability of genomics to predict toxicity, categorize chemicals, and elucidate mechanisms of toxicity. Three triazole antifungals (myclobutanil, propiconazole, and
Autor:
Christopher Lau, Michael G. Narotsky, Julie R. Thibodeaux, Andrew B. Lindstrom, John M. Rogers, Mark J. Strynar, Roger G. Hanson
Publikováno v:
Toxicological Sciences. 90:510-518
Perfluorooctanoic acid (PFOA), a member of the perfluoroalkyl acids that have wide commercial applications, has recently been detected in humans and wildlife. The current study characterizes the developmental toxicity of PFOA in the mouse. Timed-preg
Publikováno v:
Toxicological Sciences. 68:429-436
Gap junctional intercellular communication (GJIC) is the major pathway of intercellular signal transduction, and is thus important for normal cell growth and function. Recent studies have revealed a global distribution of some perfluorinated organic
Autor:
R. Woodrow Setzer, M. Leonard Mole, Robert J. Kavlock, John M. Rogers, Christopher Lau, M. Frank Copeland
Publikováno v:
Toxicological Sciences. 59:49-58
Biologically based dose-response (BBDR) models comprise one way to incorporate mechanistic information into a dose-response assessment to be used for risk assessments. The chemotherapeutic drug 5-fluorouracil (5-FU) has been used as a prototypic comp
Autor:
Dana L. Shuey, M. Leonard Mole, David H. Ellis, M. Frank Copeland, R. Woodrow Setzer, John M. Rogers, Tina R. Logsdon, Christopher Lau, Jennifer Merriman, Robert J. Kavlock, Annie M. Cameron
Publikováno v:
Toxicological Sciences. 59:37-48
Biologically based dose-response (BBDR) models represent an emerging approach to improving the current practice of human health-risk assessment. The concept of BBDR modeling is to incorporate mechanistic information about a chemical that is relevant
Autor:
Inchio Lou, John F. Wambaugh, Christopher Lau, Roger G. Hanson, Andrew B. Lindstrom, Mark J. Strynar, R. Dan Zehr, R. Woodrow Setzer, Hugh A. Barton
Publikováno v:
Toxicological Sciences; Feb2009, Vol. 107 Issue 2, p331-331, 1p