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Autor:
Kim Brint Pedersen, Jin-Ran Chen, Vasilis Vasiliou, Cole Maimone, Michelle L. Osborn, Shana Littleton, James Watt, Allison R Norman, Martin J. J. Ronis, Alexandra Denys
Publikováno v:
Toxicol Sci
Excessive ethanol consumption is a risk factor for osteopenia. Since a previous study showed that transgenic female mice with overexpression of catalase are partially protected from ethanol-mediated trabecular bone loss, we investigated the role of e
Autor:
Paul C. Howard, Sherry M. Lewis, Dong-Jin Yang, Seonggi Min, Robert P. Felton, Melis Coraggio, Shu-Chieh Hu, Mackean P. Maisha, Ralph E. Patton, Estatira Sepehr, Susan Chemerynski, R. Philip Yeager, Michelle E. Bishop, Hyun-Ki Kang, Hans Rosenfeldt, Raul A. Trbojevich, Robert H. Heflich, Yunan Tang, Kelly Davis, Mason G. Pearce, Matthew Bryant, Steven B Yee
Publikováno v:
Toxicological Sciences. 183:319-337
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the key tobacco-specific nitrosamines that plays an important role in human lung carcinogenesis. However, repeated inhalation toxicity data on NNK, which is more directly relevant to ciga
Publikováno v:
Toxicological Sciences. 183:404-414
Inhibition kinetics assays were conducted with 16 commercial organophosphate (OP) pesticides or their metabolites on acetylcholinesterase (AChE) in erythrocyte “ghost” preparations from 18 individual humans (both sexes; adults, juveniles, and cor
Autor:
Elaine Kwan, Roy Gerona, Rayyan Aburajab, June-Soo Park, Yan Zhou, Songmei Gao, Kenisha A. Puckett, Stephanie L. Gaw, Sirirak Buarpung, Julia R. Varshavsky, Tracey J. Woodruff, Joshua F. Robinson, Saunak Sen, Susan J. Fisher, Igor Zakharevich, Sabrina Crispo Smith
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology, vol 181, iss 2
Toxicol Sci
Toxicol Sci
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) and organophosphate flame retardants (OPFRs) are chemicals that may contribute to placenta-mediated complications and adverse maternal-fetal health risks. Few studies have investigated these chemi
Publikováno v:
Toxicol Sci
Phthalates are solvents and plasticizers found in consumer products including cosmetics, food/beverage containers, housing materials, etc. Phthalates are known endocrine-disrupting chemicals that can directly target the ovary, potentially causing def
Autor:
Alec McDermott, Elham Dianati, Michael G. Wade, Bernard Robaire, Isabelle Plante, Rita-Josiane Gouesse, Barbara F. Hales
Publikováno v:
Toxicological Sciences. 179:206-219
In utero and prepubertal development of the mammary glands occurs minimally in a hormone independent manner until puberty where maturation of the hypothalamic-pituitary-gonadal axis drives an extensive remodeling. Nevertheless, because the immature g
Autor:
David C. Muddiman, Kylie D. Rock, Dereje D. Jima, Heather B. Patisaul, Heather M. Stapleton, Genevieve St. Armour, Brian Horman, Allison K. Stewart, Matthew T. Ruis, Allison L. Phillips
Publikováno v:
Toxicol Sci
There is a growing need to understand the potential neurotoxicity of organophosphate flame retardants (OPFRs) and plasticizers because use and, consequently, human exposure, is rapidly expanding. We have previously shown in rats that developmental ex
Autor:
Banrida Wahlang, Matthew C. Cave, Kimberly Z. Head, Juliane I. Beier, Russell A. Prough, Jian Jin, Josiah E. Hardesty, Keith C. Falkner
Publikováno v:
Toxicol Sci
Vinyl chloride (VC), a common industrial chemical, has been associated with hemangiosarcoma and toxicant-associated steatohepatitis (TASH) in men working at rubber-production plants. Our group previously demonstrated that chronic VC inhalation at env
Publikováno v:
Toxicol Sci
Cadmium (Cd) is a heavy metal of great public health concern. Recent studies suggested a link between Cd exposure and cognitive decline in humans. The ε4 allele, compared with the common ε3 allele, of the human apolipoprotein E gene (ApoE) is assoc
Publikováno v:
Toxicol Sci
Dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyldichloroethylene (DDE) are ubiquitous in the environment and detected in tissues of living organisms. Although DDT owes its insecticidal activity to impeding closure of voltage-