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Autor:
Jennifer Hall, Jonathan A. Phillips, Warren W. Ku, Susan Emeigh Hart, Sally Koegler, Jing Yuan, Jon Hill, Parimal Pande, Brian Knight
Publikováno v:
Toxicologic pathology. 46(6)
An increased incidence of renal tubular adenomas and carcinomas was identified in the 2-year CD-1 mouse carcinogenicity study with empagliflozin (sodium-glucose transporter 2 inhibitor) in high dose (1,000 mg/kg/day) male mice. A 13-week mouse renal