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Publikováno v:
Toxicologic Pathology. 49:872-887
In preclinical toxicology studies, a “stage-aware” histopathological evaluation of testes is recognized as the most sensitive method to detect effects on spermatogenesis. A stage-aware evaluation requires the pathologist to be able to identify th
Autor:
Takeshi Kanno, Yuki Tomonari, Minoru Tsuchitani, Naoaki Yamada, Junko Sato, Tetsuro Kurotaki, Takuya Doi
Publikováno v:
Toxicologic Pathology. 48:649-655
Previously, we investigated the higher incidence of hyperplastic lesions and thymomas and histopathological resemblance of cortex–medullary structures between thymomas and normal thymuses in Wistar Hannover (WH) rats. Thymomas had pale-staining cel
Autor:
Brian Lauritzen, Birgitte M. Viuff, Shari A. Price, Lone H. Landsy, Jens Lykkesfeldt, Hermann Pelzer, Lykke Boysen, James T. Raymond
Publikováno v:
Toxicologic Pathology. 48:570-585
Administration of human protein–based drugs to animals often leads to formation of antidrug antibodies (ADAs) that may form circulating immune complexes (CICs) with the dosed protein. Circulating immune complexes can activate and bind complement (c
Autor:
Sukhdev S. Brar, June K. Dunnick, Kevin Gerrish, Ralph E. Wilson, Esra Mutlu, Daniel L. Morgan, Arun R. Pandiri, Keith R. Shockley, Thai-Vu T. Ton, Amy E. Brix, Gregory S. Travlos, Suramya Waidyanatha
Publikováno v:
Toxicol Pathol
Human exposure to pentabromodiphenyl ether (PBDE) mixture (DE-71) and its PBDE-47 congener can occur both in utero and during lactation. Here we tested the hypothesis that PBDE-induced neonatal hepatic transcriptomic alterations in Wistar Han rat pup
Autor:
Calvert Louden, Chidozie Amuzie, Alys Bradley, Kevin McDorman, Vinicius Carreira, Jing Ying Ma, Ronnie Chamanza, Brad Blankenship, Stuart W. Naylor
Publikováno v:
Toxicologic Pathology. 47:612-633
To further our understanding of the nonhuman primate kidney anatomy, histology, and incidences of spontaneous pathology, we retrospectively examined kidneys from a total of 505 control Cynomolgus monkeys ( Macaca fascicularis; 264 male and 241 female
Autor:
Arvin H. Soepriatna, Gozde Uzunalli, L. Tiffany Lyle, Alexandra M. Dieterly, Craig J. Goergen, Chinyere M Kemet
Publikováno v:
Toxicologic Pathology. 47:515-527
Vertebral metastases of non-small cell lung cancer (NSCLC) are frequently diagnosed in the metastatic setting and are commonly identified in the thoracic vertebrae in patients. Treatment of NSCLC bone metastases, which are often multiple, is palliati
Publikováno v:
Toxicologic Pathology. 47:469-482
Microminipigs have become an attractive animal model for the toxicology- and pharmacology-related studies because of their manageable size. In this study, the development of the testicular interstitium and steroidogenesis in microminipigs, from 0 to
Publikováno v:
Toxicologic Pathology. 47:174-189
The prevalence of liver and skin tumors in brown bullhead ( Ameiurus nebulosus) from the Anacostia River (Washington, DC) and nearby areas was determined in 2014, 2015, and 2016. The objectives were to (1) compare tumor prevalence across space and ti
Autor:
Mudher Albassam, Björn Jacobsen, Barbara Lenz, Christian Freichel, Jean-Christophe Hoflack, Anne Eichinger-Chapelon, Andreas Brink
Publikováno v:
Toxicologic Pathology. 47:138-149
The chemically induced accumulation of α2u-globulin protein in male rats causes specific renal lesions and subsequent nephropathy. Herein, we report additional parallel findings in the kidney of male rats consistent with obstructive and retrograde n
Autor:
Laura S. Zwick, Jill Hsiao, Chris Papagiannis, Jeffery A. Engelhardt, Noah Post, Scott P. Henry, Tae-Won Kim, John Matson, Sebastien A. Burel, Christine Hoffmaster
Publikováno v:
Toxicologic Pathology. 47:82-92
The 6-month Tg.rasH2 mouse carcinogenicity model provides an acceptable alternative to the 2-year carcinogenicity study in CD-1 mice. However, key questions related to the use of this model for testing antisense oligonucleotides (ASOs) include the si