Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kenneth H. Fischbeck"'
Autor:
Christopher Grunseich, Ram Miller, Therese Swan, David J Glass, Mohamed El Mouelhi, Mara Fornaro, Olivier Petricoul, Igor Vostiar, Ronenn Roubenoff, Matthew N Meriggioli, Angela Kokkinis, Robert D Guber, Maher S Budron, John Vissing, Gianni Soraru, Tahseen Mozaffar, Albert Ludolph, John T Kissel, Kenneth H Fischbeck, Julia Dahlqvist, Nanna Witting, Ilaria Martinelli, Giorgia Querin, Namita A Goyal, Tiyonnoh M Cash, Brian Minton, Angela Rosenbohm, Ulrike Weiland, Patrick Weydt, Sharon Chelnick, Stanley Iyadurai, Wendy King
Publikováno v:
The Lancet. Neurology. 17(12)
Summary Background Spinal and bulbar muscular atrophy is an X-linked neuromuscular disease caused by CAG repeat expansion in the androgen receptor gene. Patients with this disease have low concentrations of insulin-like growth factor-1 (IGF-1), and s
Autor:
Alice B. Schindler, Jennifer Ryder, Joseph A. Shrader, Michael O. Harris-Love, Beth Solomon, Angela Kokkinis, Cheun Ju Chen, Nicholas A. Di Prospero, Li Li, Lindsay Fernández-Rhodes, Charlotte A. Watts, Kenneth H. Fischbeck, Michelle J. White, Alison La Pean, Ellen W. Levy, Sungyoung Auh, Neal Jeffries, Tanya J. Lehky
Publikováno v:
The Lancet. Neurology. 10(2)
Summary Background Spinal and bulbar muscular atrophy (SBMA) is caused by polyglutamine expansion in the androgen receptor, which results in ligand-dependent toxicity. Animal models have a neuromuscular deficit that is mitigated by androgen-reducing