Zobrazeno 1 - 10
of 19
pro vyhledávání: ''
Autor:
Xiaosong Zhu, Jean Bennett, Chris A. Johnson, Katie Wachtel, Jean Walshire, Zi Fan Yu, Julie Pappas, Taylor Kehoe, Elliott H. Sohn, Jennifer Wellman, Vinit B. Mahajan, Bart P. Leroy, Michelle T. Weckmann, Francesca Simonelli, Okan U. Elci, Dominique Cross, Amy Tillman, J. Fraser Wright, Lindsey A. George, Kathleen A. Marshall, Julia A. Haller, Maria C. Davis, Edwin M. Stone, Janet Wittes, Laura E. Dingfield, Dina Y. Gewaily, Sarah McCague, Leslie Raffini, Katherine A. High, Albert M. Maguire, Hannah Reichert, Arlene V. Drack, Daniel C. Chung, Wanda Pfeifer, F. Parker Hudson, Stephen R. Russell
Publikováno v:
The Lancet. 390:849-860
Background Phase 1 studies have shown potential benefit of gene replacement in RPE65-mediated inherited retinal dystrophy. This phase 3 study assessed the efficacy and safety of voretigene neparvovec in participants whose inherited retinal dystrophy
Autor:
Prasheen Agarwal, Paul P. Tak, Yoshiya Tanaka, Clifton O. Bingham, Sharon Popik, Regina Kurrasch, Daniel Aletaha
Publikováno v:
The Lancet. 389:1206-1217
Sirukumab, a human monoclonal antibody that selectively binds to the interleukin-6 cytokine with high affinity, is under development for the treatment of rheumatoid arthritis and other diseases. We aimed to assess the efficacy and safety of sirukumab
Autor:
Nir Giladi, Jeffrey M. Hausdorff, Lisa Alcock, Esther M.J. Bekkers, Alice Nieuwboer, Inbal Maidan, Lynn Rochester, Marcel G. M. Olde Rikkert, Elisa Pelosin, Laura Avanzino, Giovanni Abbruzzese, Silvia Del Din, Freek Nieuwhof, Kimberly Dockx, Bastiaan R. Bloem, Anat Mirelman
Publikováno v:
The Lancet (London), 388, 1170-1182
The Lancet (London), 388, 10050, pp. 1170-1182
The Lancet (London), 388, 10050, pp. 1170-1182
Contains fulltext : 167962.pdf (Publisher’s version ) (Closed access) BACKGROUND: Age-associated motor and cognitive deficits increase the risk of falls, a major cause of morbidity and mortality. Because of the significant ramifications of falls, m
Autor:
Vincent M. Hendriks, Peter Blanken, Mascha Nuijten, Ben J.M. van de Wetering, Bastiaan Nuijen, Wim van den Brink
Publikováno v:
Lancet, 387(10034), 2226-2234. Elsevier Limited
Summary Background Heroin-assisted treatment is effective for methadone treatment-refractory heroin-dependent patients, but continued comorbid cocaine dependence remains problematic. Sustained-release dexamfetamine is a promising agonist pharmacother
Autor:
Miia Kivipelto, Francesca Mangialasche, Satu Pajala, Tuomo Hänninen, Timo E. Strandberg, Jaakko Tuomilehto, Teemu Paajanen, Hilkka Soininen, Tiia Ngandu, Esko Levälahti, Satu Ahtiluoto, Anna Stigsdotter-Neely, Jenni Lehtisalo, Lars Bäckman, Riitta Antikainen, Jaana Lindström, Markku Peltonen, Rainer Rauramaa, Tiina Laatikainen, Antti Jula, Alina Solomon
Publikováno v:
The Lancet. 385:2255-2263
Summary Background Modifiable vascular and lifestyle-related risk factors have been associated with dementia risk in observational studies. In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), a proof-o
Autor:
Arjumand Rizvi, Muneera A. Rasheed, Aisha K. Yousafzai, Robert W. Armstrong, Zulfiqar A Bhutta
Publikováno v:
The Lancet. 384:1282-1293
Stimulation and nutrition delivered through health programmes at a large scale could potentially benefit more than 200 million young children worldwide who are not meeting their developmental potential. We investigated the feasibility and effectivene
Autor:
Dewei Zhao, Simiao Tian
Publikováno v:
The Lancet. 392:S21
Background Low back pain is a major health concern in China because of its high prevalence among the general population. Exercise is universally recommended as a core treatment to reduce the symptoms, but the relative efficacy of different types of e
Autor:
K Spanjers, David R. Ellard, N Atherton, Margaret Thorogood, Rachel Potter, Stephen Bremner, Karla Diaz-Ordaz, Anne Spencer, Martin Underwood, Angela Devine, Sandra Eldridge, Stephanie Taylor, Bart Sheehan, Sarah E Lamb, Anne-Marie Slowther
Publikováno v:
Lancet
Summary Background Depression is common and is associated with poor outcomes among elderly care-home residents. Exercise is a promising low-risk intervention for depression in this population. We tested the hypothesis that a moderate intensity exerci
Autor:
Christina Holzapfel, Namson S Lau, Louise M. Aston, Ashley Olson, Nicholas R. Fuller, Adrian Mander, Susan A. Jebb, Hans Hauner, Annie E. Simpson, Suzanne Pearson, Ian D. Caterson, Amy L Ahern, Ulrike Amann-Gassner, Julia Stoll
Publikováno v:
The Lancet. 378:1485-1492
BACKGROUND: The increasing prevalence of overweight and obesity needs effective approaches for weight loss in primary care and community settings. We compared weight loss with standard treatment in primary care with that achieved after referral by th
Autor:
Yu Jiang, Hong Fang, Yingyao Chen, Xiaona Liu, Baodong Yao, Wanghong Xu, Russell L. Rothman, Qinghua Xia, Peng Zhou, Junling Gao, Yujie Yan
Publikováno v:
The Lancet. 390:S92
Background Patients with diabetes in China have low health literacy, which likely leads to poor glycaemic control and clinical outcomes. This study was designed to evaluate the effectiveness of health literacy-focused and exercise-focused interventio