Zobrazeno 11 - 20
of 35
pro vyhledávání: '"59"'
Autor:
Yasunori Shintani, Masafumi Myoishi, Shigeru Fukuzawa, Masaharu Ishihara, Natsuki Nakamura, Toshimitsu Hamasaki, Masafumi Kitakaze, Kouki Watanabe, Osamu Seguchi, Yoshiyuki Nagai, Kazuo Kimura, Tetsuo Minamino, Soichiro Kitamura, Atsushi Hirayama, Takahiro Ohara, Yoshihiko Saito, Kenshi Fujii, Shinsuke Nanto, Jiyoong Kim, Hitonobu Tomoike, Masanori Asakura, Hiroshi Asanuma
Publikováno v:
The Lancet. 370:1483-1493
Summary Background Patients who have acute myocardial infarction remain at major risk of cardiovascular events. We aimed to assess the effects of either human atrial natriuretic peptide or nicorandil on infarct size and cardiovascular outcome. Method
Publikováno v:
The Lancet. 362:1433-1438
Summary Background Episodic wheeze triggered by viral colds is common in children aged between 1 and 5 years (preschool viral wheeze). Most affected children are asymptomatic by age 6 years. Persistence of wheeze is associated with above-average syst
Autor:
Liam Donaldson, Russell Gibson, Andrew Carson-Stevens, Huw Williams, Peter Hibbert, Adrian Edwards, Maryam Azfal, Aziz Sheikh
Publikováno v:
The Lancet. 389:S38
Background The UK has the highest prevalence of illicit drug use in developed countries. Opioid replacement therapy (ORT) aims to reduce illicit opioid use, but inadequate monitoring of treatment can lead to serious preventable adverse drug reactions
Autor:
Matthias Günther, Daniel Camus, Hans Dieter Nothdurft, Neil S. Roskell, Paul D Clarke, Jeffrey D. Chulay, David Overbosch, Dea Shaw, Kevin C. Kain, Izak Joubert, Birthe Høgh
Publikováno v:
The Lancet. 356:1888-1894
Summary Background Chloroquine plus proguanil is widely used for malaria chemoprophylaxis despite low effectiveness in areas where multidrug-resistant malaria occurs. Studies have shown that atovaquone and proguanil hydrochloride is safe and effectiv
Autor:
Kenneth Egstrup, Agner E, Lars Køber, Bradley Marchant, Jørgen Videbæk, Carlsen Je, Mogens Møller, Christian Torp-Pedersen, Erik Sandoe, Poul Erik Bloch Thomsen, A. John Camm
Publikováno v:
The Lancet. 356:2052-2058
Summary Background Arrhythmias cause much morbidity and mortality after myocardial infarction, but in previous trials, antiarrhythmic drug therapy has not been convincingly effective. Dofetilide, a new class III agent, was investigated for effects on
Autor:
Masashi Goto, Takeshi Iwanaga, Toshifusa Nakajima, Tsuyoshi Kito, Kenzo Okabayashi, Michiro Sasaki, Atsushi Nashimoto, Masatsugu Kitamura
Publikováno v:
The Lancet. 354:273-277
Summary Background To study the survival benefit of adjuvant chemotherapy in gastric cancer, seven cancer centres in Japan carried out a phase III clinical trial of adjuvant chemotherapy after curative gastrectomy for macroscopically serosa-negative
Publikováno v:
The Lancet. 353:2190-2194
Summary Background There is still controversy about whether all antiepileptic drugs are associated with the severe cutaneous reactions Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). We have studied the role of antiepileptic drug
Publikováno v:
The Lancet. 353:1819-1823
Little is known about the long-term efficacy of inhaled corticosteroids in chronic obstructive pulmonary disease (COPD). We investigated the efficacy of inhaled budesonide on decline in lung function and respiratory symptoms in a 3-year placebo-contr
Autor:
Peter Reiss, Jens D Lundgren, Bruno Ledergerber, Juan Gonzales-Lahoz, Antonella d'Arminio Monforte, Ole Kirk, Rui Proença, Gerrit Jan Weverling, Andrew N. Phillips, Amanda Mocroft
Publikováno v:
The Lancet. 353:1293-1298
Summary Background Highly active antiretroviral therapy (HAART) has improved rates of CD4-lymphocyte recovery and decreased the incidence of HIV-1-related morbidity and mortality. We assessed whether prophylaxis against Pneumocystis carinii pneumonia
Autor:
Jean-Jacques Grob, Jean-Pierre Cesarini, Catherine Lok, Brigitte Dréno, Michèle Delaunay, Claude Chastang, Bernard Guillot, Pierre Souteyrand, Jean Jacques Bonerandi, Didier Cupissol, Bruno Sassolas, Sylvie Lionnet, Pauline de la Salmoniere
Publikováno v:
The Lancet. 351:1905-1910
Summary Background Owing to the limited efficacy of therapy on melanoma at the stage of distant metastases, a well-tolerated adjuvant therapy is needed for patients with high-risk primary melanoma. Our hypothesis was that an adjuvant treatment with l