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Autor:
Kathryn M. Kitrinos, Patrick Marcellin, John G. McHutchison, William Sievert, Jeffrey D. Bornstein, George Germanidis, Ira M. Jacobson, Nezam H. Afdhal, Maria Buti, G. Mani Subramanian, Edward Gane, Mary Kay Washington, E. Jenny Heathcote, Raul Aguilar Schall, John F. Flaherty
Publikováno v:
The Lancet. 381:468-475
Whether long-term suppression of replication of hepatitis B virus (HBV) has any beneficial effect on regression of advanced liver fibrosis associated with chronic HBV infection remains unclear. We aimed to assess the effects on fibrosis and cirrhosis
Autor:
James M. Boyett, John T. Sandlund, Ching-Hon Pui, Erin G. Schuetz, Mary V. Relling, Gaston K. Rivera, Michael L. Hancock, William E. Evans
Publikováno v:
The Lancet. 356:285-290
Summary Background Many antileukaemic agents or their metabolites are inactivated by liver enzymes. Most anticonvulsant drugs induce drug-metabolising enzymes and thereby increase the clearance of anticancer agents. We investigated whether anticonvul
Autor:
David B. Dunger, Anna Kernell, Caroline M Patton, Carlo L. Acerini, Otto Westphal, Martin O. Savage
Publikováno v:
The Lancet. 350:1199-1204
Summary Background Good glycaemic control in insulin-dependent diabetes mellitus (IDDM) to prevent complications may be difficult to achieve during adolescence, because abnormalities in production of growth hormone or insulin-like growth-factor-l (IG
Autor:
G. Quaghebeur, N Meadows, K Khan, S G Long, Peter J. Milla, J. Fell, Anthony Reynolds, W. J. Taylor
Publikováno v:
The Lancet. 347:1218-1221
In patients receiving long-term parenteral nutrition (PN), cholestatic disease and nervous system disorders have been associated with high blood concentrations of manganese. In such patients, the normal homoeostatic mechanisms of the liver and gut ar
Publikováno v:
The Lancet. 341:919-923
Recent observations have suggested that radon in the ambient air may cause cancers at sites other than the lung, but the evidence is indirect. We have studied site-specific cancer mortality in 4320 uranium miners in West Bohemia who have been followe
Autor:
P Nunn, R Brindle, K Wasunna, C Gilks, M Omwega, J Were, M Med, D Kibuga, S Gathua, A Imalingat, S Lucas, K McAdam
Publikováno v:
The Lancet. 337:627-630
The effects of the human immunodeficiency virus (HIV) on tuberculosis management was investigated in 227 patients initially treated with a regimen containing streptomycin, isoniazid, and thiacetazone (STH). 93 of these 227 were HIV-seropositive. 60 p
Publikováno v:
The Lancet. 336:1335-1338
Jejunal histology and the presence of serum IgA antibodies (JAB) binding to human jejunum in vitro were studied in 139 children with severe malabsorptive symptoms. Among 33 children with confirmed coeliac disease (ESPGAN criteria), 13 (93%) of 14 sam
Autor:
Wilhelm Friedrich, Jaak M. Vossen, Claude Griscelli, Anders Fasth, Roland J. Levinsky, Gareth J. Morgan, Alain Fischer, S.F. Goldman, Paul Landais, Bert Gerritsen, Fulvio Porta
Publikováno v:
The Lancet. 336:850-854
The outcome of bone-marrow transplantations (BMT) carried out between 1968 and March 1, 1989, in 183 patients with severe combined immunodeficiency (SCID) was analysed. Recipients of HLA-identical BMTs (70) had a 76% probability of survival (median f
Publikováno v:
The Lancet. 336:454-457
Glycaemic status on hospital admission was compared in 97 children with severe falciparum malaria (36 with cerebral malaria) and 89 children with other serious illnesses (32 in coma; 57 with acute pneumonia, not in coma). The frequency of hypoglycaem
Publikováno v:
The Lancet. 335:816-819
30 patients with active Crohn's disease, mean Crohn's Disease Activity Index 301 (SE 32), who would otherwise have been treated with steroids, were randomised to receive for 4 weeks either an elemental diet ('Vivonex') (n = 16) or a polymeric diet ('