Zobrazeno 1 - 10
of 15
pro vyhledávání: '"35"'
Diagnosis of Creutzfeldt-Jakob disease by two-dimensional gel electrophoresis of cerebrospinal fluid
Autor:
Monika Bodemer, Otto Windl, Sigrid Poser, Hans A. Kretzschmar, Inga Zerr, Thomas Weber, Olaf Gefeller, Markus Otto
Publikováno v:
The Lancet. 348:846-849
Summary Background The diagnosis of Creutzfeldt-Jakob disease (CJD) is based on clinical and electroencephalographic criteria which do not allow a reliable diagnosis to be made during life. Methods Serum and cerebrospinal fluid (CSF) samples were obt
Publikováno v:
The Lancet. 301:985-988
An Australia-antigen screening survey was carried out on 99 commercial blood products used in clinical-chemistry and haematology laboratories. 72% (35 of 48) of the lyophilised human sera used for quality control and distributed by eight American and
Autor:
Francis O. Walker
Publikováno v:
The Lancet. 369:218-228
Huntington's disease may present at any age, but most typically manifests between the ages of 35 and 45 years as a slowly progressive neurodegenerative movement disorder with cognitive and behavioral impairment. It is an autosomal-dominant disorder t
Autor:
Andrew B. Singleton, Nathan Pankratz, Veronika E. Michaels, Dena G. Hernandez, Cheryl Halter, Coro Paisán-Ruiz, William C. Nichols, Terry Reed, Tatiana Foroud, Shushant Jain, Alice Rudolph, Clifford W. Shults
Publikováno v:
The Lancet. 365:410-412
Summary Mutations in the leucine-rich repeat kinase 2 ( LRRK2 ) gene cause some forms of autosomal dominant Parkinson's disease. We measured the frequency of a novel mutation (Gly2019Ser) in familial Parkinson's disease by screening genomic DNA of pa
Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients
Publikováno v:
The Lancet. 340:685-689
Much of the information recorded at the time of surgery for malignant disease has been used, alone or in combination, to indicate the outlook for that patient, including probability of metastasis. However, direct evidence of tumour seeding in distant
Publikováno v:
The Lancet. 375:2050
In July, 2007, an afebrile 61-year-old man presented with a fi rst episode of a generalised convulsion. Medical history included previous smoking and haemoptysis in the previous few weeks. Laboratory blood tests, viral serology, and blood cultures we
Autor:
Cynthia T. McMurray
Publikováno v:
The Lancet. 358:S37
Huntington’s disease is one of eight hereditary and progressive neurodegenerative disorders in which the underlying mutation is a CAG expansion in the coding sequence of the gene (figure). The mutation is a “trinucleotide expansion”—ie, the n
Publikováno v:
The Lancet. 321:1409-1412
Bone-marrow granulocyte-macrophage progenitor cell proliferation and regulatory factor (colony-stimulating activity; CSA) production were assessed at presentation and, if possible, subsequently in twenty-one patients with dysmyelopoiesis and less tha
Publikováno v:
The Lancet. 320:290-293
In a study of 274 women with malignant melanoma, aged 18--54 years, and 549 matched controls in New South Wales, Australia, reported exposure to fluorescent light at work was associated with a doubling of melanoma risk (relative risk [RR] = 2.1; 95%
Publikováno v:
The Lancet. 299:458-463
Recurrent haematuria in children and young adults, in the absence of other symptoms of renal disease or urinary-tract lesions, has usually been ascribed to the pathological lesion of focal or mild proliferative glomerulonephritis. To determine whethe