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Publikováno v:
The Lancet. 362:2095-2100
More than 170 million people worldwide are chronically infected with the hepatitis C virus (HCV), which is responsible for more than 100000 cases of liver cancer per year, with similar numbers of digestive haemorrhage and ascites episodes. Major brea
Autor:
Elizabeth Hills, Theonest K. Mutabingwa, E.K. Mberu, Peter Winstanley, William M. Watkins, Eunice Nduati, Alexis Nzila
Publikováno v:
The Lancet. 358:1218-1223
Summary Background Resistance to the affordable malaria treatments chloroquine and pyrimethamine-sulfadoxine is seriously impeding malaria control through treatment in east Africa. We did an open, alternate drug allocation study to assess the efficac
Autor:
Severin Olesen Larsen, Jens Pedersen-Bjergaard, S W Hansen, Mikael Rørth, Gedske Daugaard, Preben Philip
Publikováno v:
The Lancet. 338:359-363
Among the cytostatic drugs only the alkylating agents have been firmly established as being leukaemogenic. This report describes 4 cases of acute myeloid leukaemia and 1 of myelodysplasia occurring in a cohort of 212 patients with germ-cell tumours t
Publikováno v:
The Lancet. 337:690-694
The effects of a highly selective leukotriene D4 receptor antagonist, ICI 204.219, on allergen-induced bronchoconstriction and changes in airway reactivity were evaluated in a double-blind, placebo-controlled, crossover trial. Ten atopic subjects wer
Primary interferon resistance and treatment response in chronic hepatitis C infection: a pilot study
Autor:
Christian Mueller, Peter Ferenci, Wolfgang Jessner, Thomas Watkins-Riedel, Michael Gschwantler, Alfred Gangl, Friedrich Wrba, Petra Steindl-Munda, Harald Hofer
Publikováno v:
The Lancet. 358:1241-1242
Summary Only 30% of patients with chronic hepatitis C virus genotype 1 (HCV-1) infection achieve a sustained virological response to interferon and ribavirin combination therapy. We prospectively assessed decline in viral load 24 h after one dose of
Publikováno v:
The Lancet. 341:989-990
Sulphidopeptide leukotrienes are potent bronchoconstrictors and increase bronchial hyperreactivity, one of the hallmarks of asthma. We have demonstrated that leukotriene LTE4, the most stable of the sulphidopeptide leukotrienes, elicited an increase
Publikováno v:
The Lancet. 339:1605-1606
Autor:
Sam D'Onofrio, R.David Byrum, Michael Marmor, DanielC. William, Linda Laubenstein, Neil Dubin, AlvinE. Friedman-Kien
Publikováno v:
The Lancet. 319:1083-1087
An investigation of 20 homosexual men with histologically confirmed Kaposi's sarcoma and 40 controls revealed significant associations between Kaposi's sarcoma and use of a number of drugs (amyl nitrite, ethyl chloride, cocaine, phencyclidine, methaq
Autor:
Gary Cook, Juan C. Ayus, Richard L. Tillquist, Carlos Mattioli, Michael Sullivan, DavidS. Terman, George Buffaloe
Publikováno v:
The Lancet. 314:824-827
Extracorporeal immunoadsorption and filtration was used in treatment of a 29-year-old woman with severe lupus nephritis. For the previous 35 days single-stranded DNA (ssDNA) antibody and immune-complex levels had been continuously raised with only pa
Publikováno v:
The Lancet. 320:1246-1249
Eleven patients in whom thrombocytopenia developed during heparin therapy were studied. Six patient (group 1) had severe thrombocytopenia with delayed onset and five of these patients had thromboembolic complications. A serum factor which induced hep