Zobrazeno 1 - 10
of 145
pro vyhledávání: ''
Autor:
Dawn J. Caster, Ellen M. Ginzler, Laura Lisk, Robert B Huizinga, Brad H. Rovin, Cristina Arriens, Joshua Kaplan, Neil Solomons, Y K Onno Teng, Juanita Romero-Diaz, Keisha L. Gibson, Simrat Randhawa, Samir V. Parikh, Sandra V. Navarra
Publikováno v:
The Lancet, 397(10289), 2070-2080. ELSEVIER SCIENCE INC
Background Voclosporin, a novel calcineurin inhibitor approved for the treatment of adults with lupus nephritis, improved complete renal response rates in patients with lupus nephritis in a phase 2 trial. This study aimed to evaluate the efficacy and
Autor:
Mayara Lisboa Bastos, Dick Menzies, Gregory P. Bisson, Petros Isaakidis, Stalz Charles Vilbrun, Parvaneh Baghaei, Jean W. Pape, Jonathon R. Campbell, Payam Tabarsi, Christoph Lange, Piret Viiklepp, Didi Bang, Suzanne M. Marks, Giovanni Battista Migliori, Jonathan Walsh, Domingo Palmero, James C.M. Brust
Publikováno v:
Lancet
Summary Background HIV-infection is associated with increased mortality during multidrug-resistant tuberculosis treatment, but the extent to which the use of antiretroviral therapy (ART) and anti-tuberculosis medications modify this risk are unclear.
Autor:
Gerd R Burmester, Frank Buttgereit, Corrado Bernasconi, Jose M Álvaro-Gracia, Nidia Castro, Maxime Dougados, Cem Gabay, Jacob M van Laar, Jan Michael Nebesky, Attila Pethoe-Schramm, Carlo Salvarani, Marc Y Donath, Markus R John, Arnaud Constantin, Jacques Eric Gottenberg, Sylvie Loiseau-Peres, Minh Nguyen, Thierry Schaeverbeke, Rieke H.-E. Alten, Christopher Amberger, Werner A. Biewer, Konrad Boche, Gerd Ruediger Burmester, Andreas Engel, Martin Feuchtenberger, Martin Fleck, Georg Gauler, Bernhard Heilig, Maria Höhle, Christof Iking-Konert, Peter Kästner, David Kofler, Klaus Krueger, Cornelia Kühne, Reiner Kurthen, Hendrik Schulze-Koops, Holger Schwenke, Maren Sieburg, Christof Specker, Hans-Peter Tony, Siegfried Wassenberg, Jörg Wendler, Roberto Caporali, Oscar Epis, Marco Matucci-Cerinic, Alexander Dubikov, Rimma Kamalova, Maxim Korolev, Vadim I. Mazurov, Ekaterina Puntus, Nemanja Damjanov, Tatjana Ilic, Milijanka Lazarevic, Sasa Milenkovic, Milan Petronijevic, Elyes Bouajina, Mohamed Elleuch
Publikováno v:
The Lancet, Vol. 396, No 10246 (2020) pp. 267-276
Summary Background Patients with inflammatory diseases, such as rheumatoid arthritis, often receive glucocorticoids, but long-term use can produce adverse effects. Evidence from randomised controlled trials to guide tapering of oral glucocorticoids i
Autor:
Xavier Leleu, Zandra Klippel, David S. Siegel, Maria-Victoria Mateos, Meletios A. Dimopoulos, Hang Quach, Ola Landgren, Saad Z. Usmani, Katja Weisel, Anita Zahlten-Kumeli, Hui Yang
Publikováno v:
The Lancet. 396:186-197
Summary Background Lenalidomide and bortezomib frontline exposure has raised a growing need for novel treatments for patients with relapsed or refractory multiple myeloma. Carfilzomib in combination with daratumumab has shown substantial efficacy wit
Autor:
Susan E Krown, Carlee B Moser, Patrick MacPhail, Roy M Matining, Catherine Godfrey, Stephanie R Caruso, Mina C Hosseinipour, Wadzanai Samaneka, Mulinda Nyirenda, Naftali W Busakhala, Fred M Okuku, Josphat Kosgei, Brenda Hoagland, Noluthando Mwelase, Vincent O Oliver, Henriette Burger, Rosie Mngqibisa, Mostafa Nokta, Thomas B Campbell, Margaret Z Borok, Agnes Moses, Cecilia Kanyama, Pamela Mukwekwerere, Ivy Gudza, Felluna Chauwa, Godwin Ulaya, Irene Kutto, Priscilla Cheruiyot, Clement Okello, Annet Nakaganda, Geoffrey Koskei, Winnie Keter, Juliana Netto, Tamiris Baião, Iveshni Govender, Jessica O'Connell-Maritz, Kevin Cain, John Okanda, Lynne Cornelissen, Marije Van Schalkwyk, Rejoice Sikhosana, Minenhle Ngcobo, Jeannette Y. Lee, Taylor Harrison, William Wachsman, Katherine Shin, Scott Evans, Jennifer Rothenberg, Lara Hosey, Sean McCarthy, Otoniel Martinez-Maza, Charles Rinaldo, Dirk Dittmer, Courtney Fletcher, Michelle Rudek, Aida Asmelash, Valery Hughes, Jeffrey Schouten, David Shugarts, Tapiwanashe Kujinga, Amanda Zadzilka, Fredrick Kerui, Debora Robertson, James Rooney, Krishna Sewal, Brian Gottshall
Publikováno v:
The Lancet. 395:1195-1207
Summary Background Optimal treatment regimens for AIDS-associated Kaposi sarcoma, a frequent contributor to morbidity and mortality among people with HIV, have not been systematically evaluated in low-income and middle-income countries, where the dis
Autor:
Ludwig Kappos, Amit Bar-Or, Bruce A C Cree, Robert J Fox, Gavin Giovannoni, Ralf Gold, Patrick Vermersch, Douglas L Arnold, Sophie Arnould, Tatiana Scherz, Christian Wolf, Erik Wallström, Frank Dahlke, Anat Achiron, Lutz Achtnichts, Kadriye Agan, Gulsen Akman-Demir, Alison B Allen, Jack P Antel, Alfredo Rodriguez Antiguedad, Michelle Apperson, Angela M Applebee, Guillermo Izquierdo Ayuso, Masayuki Baba, Ovidiu Bajenaru, Rodica Balasa, Belgin Petek Balci, Michael Barnett, Ann Bass, Veit U Becker, Mihaela Bejinariu, Florian Then Bergh, Arnfin Bergmann, Evanthia Bernitsas, Achim Berthele, Virender Bhan, Felix Bischof, Randall John Bjork, Gregg Blevins, Matthias Boehringer, Thomas Boerner, Robert Bonek, James D Bowen, Allen Bowling, Alexey N Boyko, Cavit Boz, Vera Bracknies, Stefan Braune, Vincenzo Brescia Morra, Bruno Brochet, Waldemar Brola, Paul Kenneth Brownstone, Miroslav Brozman, Donald Brunet, Ioan Buraga, Margaret Burnett, Mathias Buttmann, Helmut Butzkueven, Jonathan Cahill, Jonathan C Calkwood, William Camu, Mark Cascione, Giovani Castelnovo, Diego Centonze, Joao Cerqueira, Andrew Chan, Andrea Cimprichova, Stanley Cohan, Giancarlo Comi, Jill Conway, Joanna A Cooper, John Corboy, Jorge Correale, Brian Costell, David A Cottrell, Patricia K Coyle, Matthew Craner, Liying Cui, Luis Cunha, Anna Czlonkowska, Ana Martins da Silva, Joao de Sa, Jérôme de Seze, Marc Debouverie, Jan Debruyne, Danny Decoo, Gilles Defer, Tobias Derfuss, Norma H Deri, Bhupesh Dihenia, Peter Dioszeghy, Vladimir Donath, Benedicte Dubois, Martin Duddy, Pierre Duquette, Gilles Edan, Husnu Efendi, Stanton Elias, Peter J Emrich, Bonaventura Casanova Estruch, Evgeniy P Evdoshenko, Juergen Faiss, Alexander S Fedyanin, Wolfgang Feneberg, Jiske Fermont, Oscar Fernandez Fernandez, Francisco Coret Ferrer, Katharina Fink, Helen Ford, Corey Ford, Ada Francia, Mark Freedman, Benjamin Frishberg, Simonetta Galgani, George P Garmany, Klaus Gehring, Jeffrey Gitt, Claudio Gobbi, Lawrence P Goldstick, Rafael Arroyo Gonzalez, Francois Grandmaison, Nikolaos Grigoriadis, Olga Grigorova, Luigi Maria Edoardo Grimaldi, Jeffrey Gross, Katrin Gross-Paju, Mark Gudesblatt, Daniel Guillaume, Judith Haas, Viera Hancinova, Anca Hancu, Orla Hardiman, Arndt Harmjanz, Fedor R Heidenreich, G J D Hengstman, Joseph Herbert, Mark Herring, Suzanne Hodgkinson, Olaf M Hoffmann, Werner E Hofmann, William D Honeycutt, Le Hanh Hua, Dehui Huang, Yining Huang, DeRen Huang, Raymond Hupperts, Piroska Imre, Alan Keith Jacobs, Gabor Jakab, Elzbieta Jasinska, Kenichi Kaida, Jolanta Kalnina, Ara Kaprelyan, Guntis Karelis, Dimitrios Karussis, Amos Katz, Farit A Khabirov, Bhupendra Khatri, Takashi Kimura, Ilya Kister, Rasa Kizlaitiene, Eleonora Klimova, Juergen Koehler, Aparna Komatineni, Anselm Kornhuber, Krisztina Kovacs, Agnes Koves, Wojciech Kozubski, Georgi Krastev, Lauren B Krupp, Egon Kurca, Christoph Lassek, Guy Laureys, Liesly Lee, Eckart Lensch, Fritz Leutmezer, Hongzeng Li, Ralf A Linker, Michael Linnebank, Petra Liskova, Cristina Llanera, Jiahong Lu, Andreas Lutterotti, Jan Lycke, Richard Macdonell, Maciej Maciejowski, Mathias Maeurer, Rim V Magzhanov, Eva-Maria Maida, Lina Malciene, Yang Mao-Draayer, Girolama Alessandra Marfia, Clyde Markowitz, Vasileios Mastorodimos, Klotild Matyas, Jose Meca-Lallana, Juan Antonio Garcia Merino, Ioan Gheorghe Mihetiu, Ivan Milanov, Aaron E Miller, Andrejs Millers, Massimiliano Mirabella, Masanori Mizuno, Xavier Montalban, Lilina Montoya, Masahiro Mori, Stefanie Mueller, Jin Nakahara, Yuji Nakatsuji, Scott Newsome, Richard Nicholas, A Scott Nielsen, Esmaeil Nikfekr, Ugo Nocentini, Chiyoko Nohara, Kyoichi Nomura, Miroslav M Odinak, Tomas Olsson, B W van Oosten, Celia Oreja-Guevara, Patrick Oschmann, James Overell, Andrew Pachner, Gyula Panczel, Massimo Pandolfo, Caroline Papeix, Liliana Patrucco, Jean Pelletier, Raul Piedrabuena, Misha Pless, Udo Polzer, Krisztian Pozsegovits, Daiva Rastenyte, Sebastian Rauer, Gerd Reifschneider, Roberto Rey, Syed A Rizvi, Derrick Robertson, Jose Martinez Rodriguez, David Rog, Homayoun Roshanisefat, Vernon Rowe, Csilla Rozsa, Susan Rubin, Stanislaw Rusek, Francesco Saccà, Takahiko Saida, Antonio Vasco Salgado, Victoria Eugenia Fernandez Sanchez, Kalina Sanders, Maria Satori, Denis V Sazonov, Elio Angelo Scarpini, Eugen Schlegel, Myriam Schluep, Stephan Schmidt, Erich Scholz, H M Schrijver, Matthias Schwab, Raymond Schwartz, James Scott, Krzysztof Selmaj, Stuart Shafer, Basil Sharrack, Ivan A Shchukin, Yuko Shimizu, Penko Shotekov, Arno Siever, Karl-Otto Sigel, Scott Silliman, Magdolna Simo, Mihaela Simu, Vladimiro Sinay, Antonio Escartin Siquier, Aksel Siva, Ondrej Skoda, Andrew Solomon, Martin Stangel, Dusan Stefoski, Brian Steingo, Igor D Stolyarov, Pavel Stourac, Katrin Strassburger-Krogias, Erik Strauss, Olaf Stuve, Ivaylo Tarnev, Antonios Tavernarakis, Cristina Ramo Tello, Murat Terzi, Veronika Ticha, Marina Ticmeanu, Klaus Tiel-Wilck, Toomas Toomsoo, Niall Tubridy, Mark J Tullman, Hayrettin Tumani, Peter Turcani, Ben Turner, Antonio Uccelli, Francisco Javier Olascoaga Urtaza, Marta Vachova, Attila Valikovics, Silke Walter, Bart Van Wijmeersch, Ludo Vanopdenbosch, Joerg R Weber, Sara Weiss, Robert Weissert, Timothy West, Heinz Wiendl, Sandrine Wiertlewski, Brigitte Wildemann, Barbara Willekens, L H Visser, Galina Vorobeychik, Xianhao Xu, Takashi Yamamura, Yi N Yang, Sergio Martinez Yelamos, Michael Yeung, Alan Zacharias, Marvin Zelkowitz, Uwe Zettl, Meini Zhang, Hongyu Zhou, Ulf Zieman, Tjalf Ziemssen
Publikováno v:
The Lancet
The Lancet, 2018, 391 (10127), pp.1263-1273. ⟨10.1016/S0140-6736(18)30475-6⟩
The lancet : international edition
The Lancet, 2018, 391 (10127), pp.1263-1273. ⟨10.1016/S0140-6736(18)30475-6⟩
The lancet : international edition
Summary Background No treatment has consistently shown efficacy in slowing disability progression in patients with secondary progressive multiple sclerosis (SPMS). We assessed the effect of siponimod, a selective sphingosine 1-phosphate (S1P) recepto
Autor:
Syed A. Hussain, Nicholas J. Vogelzang, Margitta Retz, Xiaodong Shen, Yohann Loriot, Ugo De Giorgi, Alain Ravaud, Marjorie C. Green, Thomas Powles, Sanjeev Mariathasan, Na Cui, Gwenaelle Gravis, Aristotelis Bamias, Priti S. Hegde, Daniel Castellano, Romain Banchereau, Stéphane Oudard, Edward E. Kadel, Ignacio Duran, Aude Flechon, Christina Louise Derleth, Toshimi Takano, Ning Leng, Michiel S. van der Heijden
Publikováno v:
The Lancet. 391:748-757
Summary Background Few options exist for patients with locally advanced or metastatic urothelial carcinoma after progression with platinum-based chemotherapy. We aimed to assess the safety and efficacy of atezolizumab (anti-programmed death-ligand 1
Autor:
Bruno Scherrer, Victor Kande Betu Ku Mesu, Crispin Lumbala, Olaf Valverde Mordt, Nathalie Strub-Wourgaft, Wilfried Mutombo Kalonji, Séverine Blesson, Willy Kuziena, Jean Pierre Fina Lubaki, Steven Lumeya Vuvu, Pathou Nganzobo Ngima, Augustin Kasongo Bonama, François Simon, Lewis Kaninda Badibabi, Jean Louis Lumaliza Solomo, Medard Ilunga, Sonja C. Bernhard, Francis Regongbenga Dama, Josué Amici Heradi, Guylain Mandula, Papy Kavunga Lukula, Clélia Bardonneau, Hélène Mahenzi Mbembo, Digas Ngolo Tete, Sophie Delhomme, Antoine Tarral
Publikováno v:
The Lancet. 391:144-154
Summary Background Few therapeutic options are available to treat the late-stage of human African trypanosomiasis, a neglected tropical disease, caused by Trypanosoma brucei gambiense (g-HAT). The firstline treatment is a combination therapy of oral
Autor:
Pál Czobor, W. Wolfgang Fleischhacker, Suresh Durgam, Marc Debelle, Ágota Barabássy, István Bitter, Balázs Szatmári, E. Szalai, Judit Harsányi, Stephen R. Marder, István Laszlovszky, György Németh
Publikováno v:
The Lancet. 389:1103-1113
Summary Background Although predominant negative symptoms of schizophrenia can be severe enough to cause persistent impairment, effective treatment options are lacking. We aimed to assess the new generation antipsychotic cariprazine in adult patients
Autor:
Daniel Shao-Weng Tan, Chun-Ming Tsai, Yi-Long Wu, Luis Paz-Ares, Fabrice Branle, Denis Moro-Sibilot, Serafino Pantano, Cristian Massacesi, Diego Cortinovis, Gilberto de Castro, Rita Chiari, Sergey Orlov, Chong-Jen Yu, Juergen Wolf, Sarayut Lucien Geater, Alexis B. Cortot, Maximillian Hochmair, Rosario Garcia Campelo, Paramita Sen, Tracey McCulloch, Margaret Dugan, Jean-Charles Soria
Publikováno v:
The Lancet. 389:917-929
Summary Background The efficacy of ceritinib in patients with untreated anaplastic lymphoma kinase ( ALK )-rearranged non-small-cell lung cancer (NSCLC) is not known. We assessed the efficacy and safety of ceritinib versus platinum-based chemotherapy