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Publikováno v:
The Lancet. 368:230-239
Summary With a prevalence of 10–15% in adults in Europe and the USA, gallstones are the most common digestive disease needing admission to hospital in the West. The interplay between interprandial and postprandial physiological responses to endogen
Autor:
George Davey Smith, Andrew T. Hattersley, Ian N M Day, Nicholas J. Timpson, Shah Ebrahim, Roger M. Harbord, Debbie A Lawlor, Lyle J. Palmer, Ann Rumley, Gordon D.O. Lowe, Tom R. Gaunt
Publikováno v:
The Lancet. 366:1954-1959
BACKGROUND: Circulating C-reactive protein (CRP) is associated with the metabolic syndrome and might be causally linked to it. Our aim was to generate estimates of the association between plasma CRP and metabolic syndrome phenotypes that were free fr
Autor:
Stavros P. Loukogeorgakis, Liam Smeeth, Weiliang Chua, Juan P. Casas, Aroon D. Hingorani, Patrick Vallance, Raymond J. MacAllister
Publikováno v:
The Lancet. 366:2026-2033
BACKGROUND: A consensus has emerged that angiotensin-converting-enzyme (ACE) inhibitors and angiotensin-II receptor blockers (ARBs) have specific renoprotective effects. Guidelines specify that these are the drugs of choice for the treatment of hyper
Publikováno v:
The Lancet. 366:2058-2061
The pathogenesis of the acute Charcot foot of diabetes remains unclear. All patients with this condition have evidence of peripheral neuropathy, with loss of protective sensation and abnormal foot biomechanics. However, the acute Charcot foot is also
Autor:
Lalita Khaodhiar, Svetlana Panasyuk, Lydia Longoria, Thanh Dinh, Jenny E. Freeman, Thomas E. Lyons, Robert L. Greenman, Xiaoen Wang, John M. Giurini, Aristidis Veves
Publikováno v:
The Lancet. 366:1711-1717
Changes in the large vessels and microcirculation of the diabetic foot are important in the development of foot ulceration and subsequent failure to heal existing ulcers. We investigated whether oxygen delivery and muscle metabolism of the lower extr
Publikováno v:
Lancet, 365(9473), 1817-1820. Elsevier Limited
Yudkin, J S, Eringa, E & Stehouwer, C D A 2005, ' "Vasocrine" signalling from perivascular fat : A mechanism linking insulin resistance to vascular disease ', Lancet, vol. 365, no. 9473, pp. 1817-1820 . https://doi.org/10.1016/S0140-6736(05)66585-3
Lancet, 365(9473), 1817-1820. Elsevier Science
Yudkin, J S, Eringa, E & Stehouwer, C D A 2005, ' "Vasocrine" signalling from perivascular fat : A mechanism linking insulin resistance to vascular disease ', Lancet, vol. 365, no. 9473, pp. 1817-1820 . https://doi.org/10.1016/S0140-6736(05)66585-3
Lancet, 365(9473), 1817-1820. Elsevier Science
Adipose tissue expresses cytokines that inhibit insulin signalling pathways in liver and muscle. Obesity also results in impairment of endothelium- dependent vasodilatation in response to insulin. We propose a vasoregulatory role for local deposits o
Autor:
Roy Freeman
Publikováno v:
The Lancet. 365:1259-1270
The autonomic neuropathies are a group of disorders in which the small, lightly myelinated and unmyelinated autonomic nerve fibres are selectively targeted. Autonomic features, which involve the cardiovascular, gastrointestinal, urogenital, sudomotor
Publikováno v:
The Lancet. 365:871-875
Summary Background Hyperlactataemia during septic shock is often viewed as evidence of tissue hypoxia. However, this blood disorder is not usually correlated with indicators of perfusion or diminished with increased oxygen delivery. Muscles can gener
Autor:
Cara B. Ebbeling, Alex Kartashov, Mark A. Pereira, David R. Jacobs, Linda Van Horn, David S. Ludwig, Martha L. Slattery
Publikováno v:
The Lancet. 365:36-42
Background. Fast-food consumption has increased greatly in the USA during the past three decades. However, the effect of fast food on risk of obesity and type 2 diabetes has received little attention. We aimed to investigate the association between r
Autor:
Pieter Wouters, Greet Van den Berghe, Ilse Vanhorebeek, Christiane De Wolf-Peeters, Dieter Mesotten, Rita Vos
Publikováno v:
The Lancet. 365:53-59
Summary Background Maintenance of normoglycaemia by use of insulin reduces morbidity and mortality of patients in surgical intensive care. Studies on mitochondrial function in critical illness or diabetes suggest that effects of intensive insulin the