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Publikováno v:
The Journals of Gerontology: Series A. 77:424-432
Nitric oxide (NO)-mediated vasodilatation is a fundamental response of vasculature, however, regulation of NO signaling pathway on resistance vessels in the older adult with hypertension is still unclear. The 16-week-spontaneously hypertensive rats (
Autor:
Yea-Tzy Chen, Meng-Shan Cheng, Hung-Ming Chang, Ting-Yi Renn, Yea-Jyh Chen, Wen-Chieh Liao, Li-You Chen, I. V. Klimenkov, Chi-Te Wang, Nikolay P. Sudakov
Publikováno v:
The Journals of Gerontology: Series A. 77:235-242
Presbyphagia is age-related changes in swallowing function, which imposes a high risk of aspiration in older adults. Considering olfactory stimulation (OS) can influence behavioral activities by modulating neuronal excitability, the present study aim
Autor:
Amy L. Confides, Esther E. Dupont-Versteegden, Kyoko Hamagata, Benjamin F. Miller, Zachary R. Hettinger, Timothy A. Butterfield, Marcus M. Lawrence
Publikováno v:
J Gerontol A Biol Sci Med Sci
The inability to fully recover lost muscle mass following periods of disuse atrophy predisposes older adults to lost independence and poor quality of life. We have previously shown that mechanotherapy at a moderate load (4.5 N) enhances muscle mass r
Autor:
Johnny P Do, Samuel M. Cadena, Laura Schaevitz, Polina Stolyar, Mark D Rabe, Szczepan W Baran, Maria A Lim
Publikováno v:
The Journals of Gerontology: Series A. 76:1206-1213
To understand the growing needs of an aging human population, there is demand for scalable and reproducible approaches to study animal models of aging and to test novel therapeutic interventions. We investigated the sensitivity and utility of a conti
Publikováno v:
The Journals of Gerontology: Series A. 76:385-392
Renal aging is a natural process that can lead to structural changes and functional decline in the kidneys. These age-related changes are considered irreversible physiological processes, but resemble diseased kidneys. To enhance understanding of the
Autor:
Svyatoslav Dvoretskiy, M. Carmen Valero, Samuel Lapp, M S Stephen D Hauschka, Yu-Fu Wu, Heather D. Huntsman, Marni D. Boppart, Ziad S. Mahmassani, Dean J. Burkin, Koyal Garg
Publikováno v:
J Gerontol A Biol Sci Med Sci
Anabolic resistance to a mechanical stimulus may contribute to the loss of skeletal muscle mass observed with age. In this study, young and aged mice were injected with saline or human LM-111 (1 mg/kg). One week later, the myotendinous junction of th
Autor:
David Lusseau, Jing-Dong J. Han, John R. Speakman, Yingchun Wang, Cara L Green, Davina Derous, Luonan Chen, Alex Douglas, Daniel E. L. Promislow, Libia Alejandra García-Flores, Sharon E. Mitchell
Publikováno v:
J Gerontol A Biol Sci Med Sci
Calorie restriction (CR) remains the most robust intervention to extend life span and improve healthspan. Though the cerebellum is more commonly associated with motor control, it has strong links with the hypothalamus and is thought to be associated
Publikováno v:
J Gerontol A Biol Sci Med Sci
The inability of older adults to maintain independence is a consequence of sarcopenia and frailty. In order to identify the molecular mechanisms responsible for decreased physical function, it will be critical to utilize a small animal model. The mai
Autor:
Spencer R. Keilich, Laura Haynes, Mark S. Miller, Jenna M. Bartley, Olivia R Ringham, Chad R. Straight, George A. Kuchel
Publikováno v:
J Gerontol A Biol Sci Med Sci
Skeletal muscle myopathies represent a common non-pulmonary manifestation of influenza infection, leading to reduced physical function and hospitalization in older adults. However, underlying mechanisms remain poorly understood. Our study examined th
Autor:
Gustavo Duque, Ahmed Al Saedi, Pierrette Gaudreau, Guylaine Ferland, Stéphanie Miard, Frédéric Picard, Daniel Rivas
Publikováno v:
J Gerontol A Biol Sci Med Sci
Long-term caloric restriction (CR) has been shown to be beneficial to various tissues and organs. In contrast, CR exerts differential effects on bone, which could be due in part to the nature of the protein regime utilized. Male Sprague Dawley rats (