Zobrazeno 1 - 10
of 201
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Publikováno v:
J Steroid Biochem Mol Biol
Luteinizing hormone and human chorionic gonadotropin (hCG) bind to the luteinizing hormone/chorionic gonadotropin receptor (LHCGR). LHCGR is required to maintain corpus luteum function but the mechanisms involved in the regulation of LHCGR in human l
Autor:
Rainer B. Lanz, Maria M. Szwarc, Francesco J. DeMayo, Qianxing Mo, John P. Lydon, William E. Gibbons, Lan Hai
Publikováno v:
J Steroid Biochem Mol Biol
Mouse studies support a role for endometrial early growth response 1 (EGR1) in uterine receptivity and decidualization, which are processes controlled by estrogen and progesterone. However, the importance of this transcription factor in similar cellu
5-Lipoxygenase (ALOX5): Genetic susceptibility to type 2 diabetes and vitamin D effects on monocytes
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 187:52-57
The arachidonate 5-lipoxygenase (ALOX5) pathway has been implicated in chronic inflammatory disease which may be influenced by vitamin D due to vitamin D response elements (VDRE). We investigated an ALOX5 polymorphism (rs4987105) in patients with typ
Autor:
Dana P Cook, Conny Gysemans, Guy Eelen, Gabriela B Ferreira, Sucheta Telang, Chantal Mathieu, An-Sofie Vanherwegen, Peter Carmeliet, Bart O. Roep, Bart Ghesquière, Tanja Nikolic
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 187:134-145
Tolerogenic dendritic cells (tolDCs) instruct regulatory T cells (Tregs) to dampen autoimmunity. Active vitamin D3 (1α,25-dihydroxyvitamin D3; 1α,25(OH)2D3) imprints human monocyte-derived DCs with tolerogenic properties by reprogramming their gluc
Autor:
Michael D. West, Hal Sternberg, Nyam Osor Chimge, Sara H Windahl, Yonatan Amzaleg, Anna E. Törnqvist, Aysha B. Khalid, Susan A. Krum, Jie Ji, Dustin E. Schones, Donlaporn Kittivanichkul, John A. Katzenellenbogen, Yankel Gabet, Baruch Frenkel, Claes Ohlsson, Elias Sabag
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 183:10-17
Estrogens attenuate bone turnover by inhibiting both osteoclasts and osteoblasts, in part through antagonizing Runx2. Apparently conflicting, stimulatory effects in osteoblast lineage cells, however, sway the balance between bone resorption and bone
Autor:
Fortune Kohen, Naftali Stern, Asaf Aizic, Dalia Somjen, Orli Sharon, Elena Izkhakov, Esther Knoll, Dan M. Fliss
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 182:81-86
Background Sorafenib improves progression-free survival in patients with progressive radioactive iodine-refractory differentiated thyroid carcinoma, but causes severe side effects. Estrogens may accelerate thyroid carcinoma cell growth. Our group rec
Autor:
Mark-Tilmann Seitz, Johannes Beismann, Heide Siggelkow, Martina Blaschke, Angelique Kragl, Regine Koepp, Frank Streit, Georg Manthey
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 210
11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) plays an important role in pre-receptor glucocorticoid metabolism. This enzyme is expressed in bone, increases with age, and catalyzes the conversion of the inactive glucocorticoid cortisone into the ac
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 174:9-13
To further investigate the interaction between vitamin D system and estrogen-mimetic compounds in the human vasculature we studied the effect of the "less- calcemic" analog of 1,25(OH)2D3 (1,25D); JK 1624F2-2 (JKF) in the presence of selective estrog
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 173:139-147
Vitamin D has so far not fulfilled its early promise as an antineoplastic agent, in spite of compelling in vitro data. With the aim of bringing vitamin D or its derivatives (VDDs) effectively to the clinic, we developed a two-pronged approach. First,
Autor:
Jiaye Zhang, Yan Chen, Fan Yang, Yingying Xu, Yuanqi Zhuang, Tingcai Pan, Xiaorui Yu, Guodong Wang, Zhen Yang, Fang Yuan, Yin-xiong Li, Xinping Huang, Ning Wang, Yue Xiong, Kai You
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 211:105881
Human hepatocyte-like cells (HLCs) derived from human pluripotent stem cells (hPSCs) represent a promising cell source for the assessment of hepatotoxicity and pharmaceutical safety testing. However, the hepatic functionality of HLCs remains signific